GPSM2

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.^[5][6][7]

GPSM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SF4, 4WNE, 4WNF, 4WNG, 5A6C
Identifiers
Aliases	GPSM2, CMCS, DFNB82, LGN, PINS, G-protein signaling modulator 2, G protein signaling modulator 2
External IDs	OMIM: 609245; MGI: 1923373; HomoloGene: 56584; GeneCards: GPSM2; OMA:GPSM2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,875,350 bp[1] End 108,934,545 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,585,954 bp[2] End 108,629,625 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia buccal mucosa cell amniotic fluid tendon of biceps brachii ventricular zone endothelial cell corpus callosum Achilles tendon internal globus pallidus inferior ganglion of vagus nerve Top expressed in neural layer of retina retinal pigment epithelium genital tubercle ventricular zone tail of embryo hair follicle Paneth cell photoreceptor layer of retina tunica media of zone of aorta condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein alpha-subunit binding nucleotide binding protein binding GTPase regulator activity identical protein binding GDP-dissociation inhibitor activity dynein complex binding protein C-terminus binding protein domain specific binding protein self-association Cellular component mitotic spindle pole spindle pole cytoskeleton cytosol cytoplasm cell cortex region cell cortex lateral cell cortex plasma membrane membrane lateral plasma membrane centrosome protein-containing complex Biological process mitotic spindle organization G protein-coupled receptor signaling pathway maintenance of centrosome location regulation of catalytic activity Ran protein signal transduction regulation of mitotic spindle organization positive regulation of protein localization to cell cortex positive regulation of spindle assembly cell cycle cell division establishment of mitotic spindle orientation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29899 76123 Ensembl ENSG00000121957 ENSMUSG00000027883 UniProt P81274 Q8VDU0 RefSeq (mRNA) NM_013296 NM_001321038 NM_001321039 NM_029522 RefSeq (protein) NP_001307967 NP_001307968 NP_037428 NP_037428.3 NP_001307967.1 NP_001307968.1 NP_083798 Location (UCSC) Chr 1: 108.88 – 108.93 Mb Chr 3: 108.59 – 108.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]^[7]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1^[8] and GNAI2.^[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000121957 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027883 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
6. Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
7. "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".
8. Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568. S2CID 7955950.
9. Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

Further reading

• Du Q, Stukenberg PT, Macara IG (2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568. S2CID 7955950.
• Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
• Kaushik R, Yu F, Chia W, Yang X, Bahri S (2003). "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
• Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540. S2CID 12900159.
• Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem. 280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID 15632202.
• Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T (2005). "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population". J. Hypertens. 23 (8): 1497–505. doi:10.1097/01.hjh.0000174606.41651.ae. PMID 16003176. S2CID 21266973.
• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.

External links

• Overview of all the structural information available in the PDB for UniProt: P81274 (Human G-protein-signaling modulator 2) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q8VDU0 (Mouse G-protein-signaling modulator 2) at the PDBe-KB.