GNAI2

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.^[5][6][7]

GNAI2
Identifiers
Aliases	GNAI2, GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1, G protein subunit alpha i2, HG1C
External IDs	OMIM: 139360; MGI: 95772; HomoloGene: 55539; GeneCards: GNAI2; OMA:GNAI2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,226,292 bp[1] End 50,259,362 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.43 cM Start 107,491,324 bp[2] End 107,512,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right lung stromal cell of endometrium C1 segment right coronary artery upper lobe of left lung thoracic aorta Descending thoracic aorta ascending aorta Top expressed in Ileal epithelium granulocyte external carotid artery lactiferous gland internal carotid artery median eminence entorhinal cortex perirhinal cortex choroid plexus of fourth ventricle corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding G-protein beta/gamma-subunit complex binding signal transducer activity metal ion binding protein binding guanyl nucleotide binding G protein-coupled receptor binding GTP binding GTPase activity Cellular component cytoplasm cell body extracellular vesicle centrosome membrane plasma membrane nucleoplasm microtubule organizing center dendrite midbody heterotrimeric G-protein complex membrane raft extracellular exosome cytoskeleton nucleus cytosol Biological process gamma-aminobutyric acid signaling pathway G protein-coupled acetylcholine receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled adenosine receptor signaling pathway negative regulation of adenylate cyclase activity intracellular signal transduction regulation of calcium ion transport adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway response to nutrient adenylate cyclase-modulating G protein-coupled receptor signaling pathway negative regulation of synaptic transmission cell division positive regulation of cell population proliferation cell cycle cell population proliferation signal transduction protein folding adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cell migration positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of calcium ion-dependent exocytosis positive regulation of insulin receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process negative regulation of protein tyrosine phosphatase activity positive regulation of vascular associated smooth muscle cell proliferation positive regulation of neural precursor cell proliferation negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2771 14678 Ensembl ENSG00000114353 ENSMUSG00000032562 UniProt P04899 P08752 RefSeq (mRNA) NM_002070 NM_001166425 NM_001282617 NM_001282618 NM_001282619 NM_001282620 NM_008138 RefSeq (protein) NP_001159897 NP_001269546 NP_001269547 NP_001269548 NP_001269549 NP_002061 NP_032164 Location (UCSC) Chr 3: 50.23 – 50.26 Mb Chr 9: 107.49 – 107.51 Mb PubMed search [3] [4]
Wikidata
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Interactions

GNAI2 has been shown to interact with:

• EYA2^[8]
• GPSM2^[9][10]
• Interleukin 8 receptor, alpha^[11][12]
• MDFI^[13]
• RGS5^[14][15]
• RIC8A^[16]