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Chemical compound From Wikipedia, the free encyclopedia
Choline chloride is an organic compound with the formula [(CH3)3NCH2CH2OH]+Cl−. It is a quaternary ammonium salt, consisting of choline cations ([(CH3)3NCH2CH2OH]+) and chloride anions (Cl−). It is a bifunctional compound, meaning, it contains both a quaternary ammonium functional group and a hydroxyl functional group. The anion of this salt, choline, occurs in nature in living beings.[2] Choline chloride is a white, water-soluble salt used mainly in animal feed.[3]
Names | |
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Preferred IUPAC name
2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride | |
Other names
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Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.596 |
E number | E1001(iii) (additional chemicals) |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
[(CH3)3NCH2CH2OH]+Cl− | |
Molar mass | 139.62 g·mol−1 |
Appearance | White hygroscopic crystals |
Melting point | 302 °C (576 °F; 575 K) (decomposes) |
very soluble (>650 g/L)[1] | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards |
Corrosive |
GHS labelling: | |
Danger | |
NFPA 704 (fire diamond) | |
Safety data sheet (SDS) | External MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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In the laboratory, choline can be prepared by methylation of dimethylethanolamine with methyl chloride.
Choline chloride is mass-produced with world production estimated at 160 000 tons in 1999.[3] Industrially, it is produced by the reaction of ethylene oxide, hydrogen chloride, and trimethylamine,[4] or from the pre-formed salt:[5]
Choline chloride can also be made by treating trimethylamine with 2-chloroethanol.[6]
It is an important additive in feed especially for chickens where it accelerates growth. It forms a deep eutectic solvent with urea, ethylene glycol, glycerol, and many other compounds.
It is also used as a clay control additive in fluids used for hydraulic fracturing.[7]
Other commercial choline salts are choline hydroxide and choline bitartrate. In foodstuffs, the compound is often present as phosphatidylcholine.
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