CSNK2A2

See also: Casein kinase 2

Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene.^[5][6]

CSNK2A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E3B, 3OFM, 3U87
Identifiers
Aliases	CSNK2A2, CK2A2, CSNK2A1, CK2alpha', casein kinase 2 alpha 2
External IDs	OMIM: 115442; MGI: 88547; HomoloGene: 20444; GeneCards: CSNK2A2; OMA:CSNK2A2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 58,157,907 bp[1] End 58,198,106 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5- D1|8 47.12 cM Start 96,172,724 bp[2] End 96,216,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte left testis right testis skin of leg sperm skin of thigh skin of arm skin of abdomen body of pancreas ganglionic eminence Top expressed in Rostral migratory stream tail of embryo spermatocyte primary oocyte zygote epiblast spermatid genital tubercle lip internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein N-terminus binding kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytosol PcG protein complex nucleoplasm chromatin acrosomal vesicle nucleus cytoplasm plasma membrane Biological process regulation of transcription, DNA-templated phosphorylation positive regulation of protein targeting to mitochondrion Wnt signaling pathway transcription, DNA-templated protein phosphorylation regulation of autophagy of mitochondrion cell cycle apoptotic process regulation of signal transduction by p53 class mediator protein folding phosphatidylcholine biosynthetic process spermatogenesis cerebral cortex development liver regeneration regulation of cell cycle macroautophagy regulation of chromosome separation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1459 13000 Ensembl ENSG00000070770 ENSMUSG00000046707 UniProt P19784 O54833 RefSeq (mRNA) NM_001896 NM_009974 RefSeq (protein) NP_001887 NP_034104 Location (UCSC) Chr 16: 58.16 – 58.2 Mb Chr 8: 96.17 – 96.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CSNK2A2 has been shown to interact with over 160 different substrates.^[7]

CSNK2A2 has been shown to interact with:

• Activating transcription factor 2,^[8]
• ATF1,^[8]
• C-Fos,^[8]
• CREB binding protein,^[8]
• CSNK2B,^[9][10][11]
• FGF1,^[12]
• Nucleolin,^[13]
• PIN1,^[14]
• PTEN,^[12][15] and
• RELA.^[16]

References

1. GRCh38: Ensembl release 89: ENSG00000070770 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046707 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lozeman FJ, Litchfield DW, Piening C, Takio K, Walsh KA, Krebs EG (Jan 1991). "Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II". Biochemistry. 29 (36): 8436–47. doi:10.1021/bi00488a034. PMID 2174700.
6. Yang-Feng TL, Zheng K, Kopatz I, Naiman T, Canaani D (Feb 1992). "Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit". Nucleic Acids Res. 19 (25): 7125–9. doi:10.1093/nar/19.25.7125. PMC 332535. PMID 1766873.
7. Faust M, Montenarh M (September 2000). "Subcellular localization of protein kinase CK2. A key to its function?". Cell Tissue Res. 301 (3): 329–40. doi:10.1007/s004410000256. PMID 10994779. S2CID 11394831.
8. Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (August 1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. PMC 147779. PMID 9685505.
9. Kim MS, Lee YT, Kim JM, Cha JY, Bae YS (February 1998). "Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro". Mol. Cells. 8 (1): 43–8. doi:10.1016/S1016-8478(23)13390-5. PMID 9571630.
10. Marin O, Meggio F, Sarno S, Pinna LA (June 1997). "Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit". Biochemistry. 36 (23): 7192–8. doi:10.1021/bi962885q. PMID 9188720.
11. Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW (May 2000). "Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2". J. Biol. Chem. 275 (19): 14295–306. doi:10.1074/jbc.275.19.14295. PMID 10799509.
12. Skjerpen CS, Nilsen Trine, Wesche Jørgen, Olsnes Sjur (Aug 2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. 21 (15). England: 4058–69. doi:10.1093/emboj/cdf402. ISSN 0261-4189. PMC 126148. PMID 12145206.
13. Li D, Dobrowolska G, Krebs EG (June 1996). "The physical association of casein kinase 2 with nucleolin". J. Biol. Chem. 271 (26): 15662–8. doi:10.1074/jbc.271.26.15662. PMID 8663258.
14. Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW (June 2002). "Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions". J. Biol. Chem. 277 (25): 23054–64. doi:10.1074/jbc.M200111200. PMID 11940573.
15. Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG (September 2002). "Direct identification of PTEN phosphorylation sites". FEBS Lett. 528 (1–3): 145–53. doi:10.1016/S0014-5793(02)03274-X. PMID 12297295. S2CID 1093672.
16. Wang D, Westerheide SD, Hanson JL, Baldwin AS (October 2000). "Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II". J. Biol. Chem. 275 (42): 32592–7. doi:10.1074/jbc.M001358200. PMID 10938077.

External links

• Human CSNK2A1 genome location and CSNK2A1 gene details page in the UCSC Genome Browser.
• Human CSNK2A2 genome location and CSNK2A2 gene details page in the UCSC Genome Browser.

Further reading

• Allende JE, Allende CC (1995). "Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation". FASEB J. 9 (5): 313–23. doi:10.1096/fasebj.9.5.7896000. PMID 7896000. S2CID 36327541.
• Faust M, Montenarh M (2001). "Subcellular localization of protein kinase CK2. A key to its function?". Cell Tissue Res. 301 (3): 329–40. doi:10.1007/s004410000256. PMID 10994779. S2CID 11394831.