BRD2

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals ^[5][6][7]

BRD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X0J, 2DVQ, 2DVR, 2DVS, 2DVV, 2E3K, 2G4A, 2YDW, 2YEK, 3AQA, 3ONI, 4A9E, 4A9F, 4A9H, 4A9I, 4A9J, 4A9M, 4A9N, 4A9O, 4AKN, 4ALG, 4ALH, 4J1P, 4MR5, 4MR6, 4QEU, 4QEV, 4QEW, 4UYF, 4UYG, 4UYH, 5BT5, 5DFD, 5HEM, 5DFB, 5HEL, 5HFQ, 5HEN, 5DFC, 5IG6, 5IBN, 5DW1
Identifiers
Aliases	BRD2, D6S113E, FSH, FSRG1, NAT, RING3, RNF3, O27.1.1, bromodomain containing 2, BRD2-IT1
External IDs	OMIM: 601540; MGI: 99495; HomoloGene: 74540; GeneCards: BRD2; OMA:BRD2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,968,594 bp[1] End 32,981,505 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,330,997 bp[2] End 34,341,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone granulocyte ganglionic eminence left lobe of thyroid gland right testis right lobe of thyroid gland left testis Pituitary Gland anterior pituitary cerebellar hemisphere Top expressed in tail of embryo genital tubercle Rostral migratory stream lacrimal gland internal carotid artery neural layer of retina ventricular zone yolk sac external carotid artery granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding lysine-acetylated histone binding Cellular component cytoplasm nucleus nucleoplasm nuclear speck Biological process regulation of transcription by RNA polymerase II nucleosome assembly regulation of transcription, DNA-templated transcription, DNA-templated spermatogenesis chromatin organization viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6046 14312 Ensembl ENSG00000215077 ENSG00000234507 ENSG00000230678 ENSG00000204256 ENSG00000235307 ENSG00000236227 ENSG00000234704 ENSMUSG00000024335 UniProt P25440 Q7JJ13 RefSeq (mRNA) NM_001113182 NM_001199455 NM_001199456 NM_001291986 NM_005104 NM_001025387 NM_001204973 NM_010238 RefSeq (protein) NP_001106653 NP_001186384 NP_001186385 NP_001278915 NP_005095 NP_001191902 NP_034368 Location (UCSC) Chr 6: 32.97 – 32.98 Mb Chr 17: 34.33 – 34.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.^[7]

Functions

• BRD2 has been implicated in cancer.^[5][8]
• BRD2 loss in mice causes obesity without diabetes for unknown reasons.^[5]
• BRD2 may have functional overlap with close homolog BRD3.^[9]
• BRD2 function is blocked by BET inhibitors.

Interactions

BRD2 has been shown to interact with E2F2,^[10][11] and many transcription factors including GATA1.^[9]