Auwers synthesis

From Wikipedia, the free encyclopedia

Auwers synthesis

The Auwers synthesis is a series of organic reactions forming a flavonol from a coumarone. This reaction was first reported by Karl von Auwers in 1908.[1][2][3][4][5]

Thumb
The Auwers synthesis
Quick Facts Identifiers ...
Auwers synthesis
Named after Karl von Auwers
Reaction type Coupling reaction
Identifiers
RSC ontology ID RXNO:0000474
Close

The first step in this procedure is an acid catalyzed aldol condensation between benzaldehyde and a 3-cyclooxapentanone to an o-hydroxychalcone. Bromination of the alkene group gives a dibromo-adduct which rearranges to the flavonol by reaction with potassium hydroxide.

Mechanism

A possible mechanism for the rearrangement step is shown below:

Thumb
Mechanism

See also

References

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.