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This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.[1]
| Doubles | |
|---|---|
| 2022 Cali Open | |
| Champions |  Malek Jaziri Adrián Menéndez Maceiras |
| Runners-up |  Keegan Smith Evan Zhu |
| Score | 7–5, 6–4 |
Malek Jaziri and Adrián Menéndez Maceiras won the title after defeating Keegan Smith and Evan Zhu 7–5, 6–4 in the final.
Sriram Balaji / Jeevan Nedunchezhiyan (semifinals)
Chung Yun-seong / 
Michail Pervolarakis (first round)
Carlos Gómez-Herrera / 
Roberto Quiroz (withdrew)
Mateus Alves / 
Nicolás Mejía (first round)
Viktor Durasovic / 
Gonçalo Oliveira (semifinals)
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 |  S Balaji J Nedunchezhiyan
| w/o | |||||||||||||||||||||||||
 P Krstin M Zekić
| 1 | S Balaji J Nedunchezhiyan
| 7 | 4 | |||||||||||||||||||||||
| Alt |  N Nakagawa Kosuke Ogura
| 63 | 5 |  I Carou F Mena
| 5 | 2r | |||||||||||||||||||||
| I Carou F Mena
| 77 | 7 | 1 | S Balaji J Nedunchezhiyan
| 4 | 6 | [6] | ||||||||||||||||||||
| 4 |  M Alves N Mejía
| 64 | 3 | Alt | K Smith E Zhu
| 6 | 1 | [10] | |||||||||||||||||||
| Alt | K Smith E Zhu
| 77 | 6 | Alt | K Smith E Zhu
| w/o | |||||||||||||||||||||
| JP Ficovich Matías Zukas
| 6 | 5 | [10] | JP Ficovich M Zukas
| |||||||||||||||||||||||
| Alt |  Blu Baker K Pannu
| 4 | 7 | [6] | Alt | K Smith E Zhu
| 5 | 4 | |||||||||||||||||||
| Facundo Juárez G Villanueva
| 7 | 65 | [7] | M Jaziri A Menéndez Maceiras
| 7 | 6 | |||||||||||||||||||||
| Alt | A Kovacevic Fernando Yamacita
| 5 | 77 | [10] | Alt | A Kovacevic F Yamacita
| 4 | 4 | |||||||||||||||||||
| Alt | Ignacio Monzón Juan Bautista Otegui
| 1 | 4 | 5 |  V Durasovic G Oliveira
| 6 | 6 | ||||||||||||||||||||
| 5 | V Durasovic G Oliveira
| 6 | 6 | 5 | V Durasovic G Oliveira
| 3 | 2 | ||||||||||||||||||||
| F Meligeni Alves J Menezes
| M Jaziri A Menéndez Maceiras
| 6 | 6 | ||||||||||||||||||||||||
| WC | Mateo Gómez A Urrea
| w/o | WC | M Gómez A Urrea
| 3 | 66 | |||||||||||||||||||||
| M Jaziri A Menéndez Maceiras
| 1 | 6 | [10] | M Jaziri A Menéndez Maceiras
| 6 | 78 | |||||||||||||||||||||
| 2 |  Y-s Chung M Pervolarakis
| 6 | 4 | [8] | |||||||||||||||||||||||
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