User:Mr. Ibrahem/Varenicline
From Wikipedia, the free encyclopedia
Varenicline, sold under the trade name Champix among others, is a medication used help people stop smoking.[1] It is the recommended initial treatment together with behavioral support.[2][3] It helps one of every 11 people who smoke, stop for at least six months.[4] Varenicline is taken by mouth.[1]
Clinical data | |
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Trade names | Champix, Chantix, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a606024 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Protein binding | <20% |
Metabolism | Limited (<10%) |
Elimination half-life | 24 hours |
Excretion | Kidney (81–92%) |
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Chemical and physical data | |
Formula | C13H13N3 |
Molar mass | 211.267 g·mol−1 |
3D model (JSmol) | |
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NY (what is this?) (verify) |
Common side effects include unusual dreams, nausea, and constipation.[1] Serious side effects may include depression, anxiety, seeing or hearing things that others do not, allergic reactions, thoughts of suicide, and seizures.[1] There is no clear harm from use in human pregnancy but such use has not been well studied and there may be harm in pregnancy in other animals.[5] It works by binding to a type of nicotinic acetylcholine receptors in the brain, decreasing the ability of nicotine to attach, and thus reducing the desire to smoke.[1]
Varenicline was approved for medical use in the United States and Europe in 2006.[1][6] It is on the World Health Organization's List of Essential Medicines.[7] As of 2020 it costs about 440 USD in the United States for the first month (7.60 USD per tablet).[8][9] In the United Kingdom this amount is about 55 pounds.[3] It may become avaliable as a generic medication in the US in 2020.[8]