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Trengestone
Chemical compound / From Wikipedia, the free encyclopedia
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Trengestone, sold under the brand names Reteroid, Retroid, and Retrone, is a progestin medication which was formerly used to treat menstrual disorders but is now no longer marketed.[4][5][6][7][8] It is taken by mouth.[9]
Quick Facts Clinical data, Trade names ...
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Clinical data | |
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Trade names | Reteroid, Retroid, Retrone |
Other names | Ro 4-8347; Triengestone; 1,6-Didehydro-6-chlororetroprogesterone; 6-Chloro-9β-10α-pregna-1,4,6-triene-3,20-dione |
Routes of administration | By mouth |
Drug class | Progestogen; Progestin |
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Bioavailability | ≥41–46% (based on urinary excretion)[1] |
Metabolism | Liver[2][3] |
Metabolites | • 20α-Dihydrotrengestone[1] |
Elimination half-life | • Trengestone: very short[1] • 20α-DHTG: 8–14 hours[1] |
Excretion | Urine: 41–46%[1] Feces: 30% (unchanged)[1] |
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ECHA InfoCard | 100.023.617 ![]() |
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Formula | C21H25ClO2 |
Molar mass | 344.88 g·mol−1 |
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Side effects of trengestone include headache, fatigue, and breast tenderness among others.[7] Trengestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.[7] It is not androgenic or estrogenic.[7]
Trengestone was introduced for medical use in 1974.[5] It is no longer available.[8]