Suzuki reaction
Cross-coupling reaction between boronic acid & an organohalide / From Wikipedia, the free encyclopedia
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The Suzuki reaction or Suzuki coupling is an organic reaction that uses a palladium complex catalyst to cross-couple a boronic acid to an organohalide.[1][2][3] It was first published in 1979 by Akira Suzuki, and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their contribution to the discovery and development of noble metal catalysis in organic synthesis.[4] This reaction is sometimes telescoped with the related Miyaura borylation; the combination is the Suzuki–Miyaura reaction. It is widely used to synthesize polyolefins, styrenes, and substituted biphenyls.
Suzuki reaction | |
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Named after | Akira Suzuki |
Reaction type | Coupling reaction |
Identifiers | |
Organic Chemistry Portal | suzuki-coupling |
RSC ontology ID | RXNO:0000140 |
The general scheme for the Suzuki reaction is shown below, where a carbon-carbon single bond is formed by coupling a halide (R1-X) with an organoboron species (R2-BY2) using a palladium catalyst and a base. The organoboron species is usually synthesized by hydroboration or carboboration, allowing for rapid generation of molecular complexity.
![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/8/8f/Suzuki_reaction_scheme_ACS.png/640px-Suzuki_reaction_scheme_ACS.png)
Several reviews have been published describing advancements and the development of the Suzuki reaction.[5][6][7]