SIBLING proteins

The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin. Evidence shows that these proteins play key roles in the mineralization of these tissues.^[1]

The following are categorized as SIBLING proteins:^[1][2]

1. osteopontin (OPN)
2. bone sialoprotein (BSP)
3. dentin matrix protein 1 (DMP1)
4. dentin sialophosphoprotein (DSPP)
5. matrix extracellular phosphoglycoprotein (MEPE)

The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.^[3]

References

1. Qin, C.; Baba, O.; Butler, W.T. (2004). "Post-Translational Modifications of Sibling Proteins and Their Roles in Osteogenesis and Dentinogenesis". Critical Reviews in Oral Biology & Medicine. 15 (3): 126–36. doi:10.1177/154411130401500302. PMID 15187031.
2. Chaplet, M; De Leval, L; Waltregny, D; Detry, C; Fornaciari, G; Bevilacqua, G; Fisher, LW; Castronovo, V; Bellahcène, A (2003). "Dentin Matrix Protein 1 is Expressed in Human Lung Cancer". Journal of Bone and Mineral Research. 18 (8): 1506–12. doi:10.1359/jbmr.2003.18.8.1506. PMID 12929940. S2CID 24870810. INIST 15005341.
3. Rittling, Susan R.; Denhardt, David T. (1999). "Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice". Nephron Experimental Nephrology. 7 (2): 103–13. doi:10.1159/000020591. PMID 10213864. S2CID 19785030.