MEPE

This article is about the gene and protein. For other uses, see mepe (disambiguation).

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.^[5][6] A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.^[7]

MEPE
Identifiers
Aliases	MEPE, OF45, matrix extracellular phosphoglycoprotein
External IDs	OMIM: 605912; MGI: 2137384; HomoloGene: 10623; GeneCards: MEPE; OMA:MEPE - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 87,821,398 bp[1] End 87,846,814 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 104,473,195 bp[2] End 104,486,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia periodontal fiber trabecular bone cingulate gyrus anterior cingulate cortex Brodmann area 23 Brodmann area 9 prefrontal cortex middle temporal gyrus superior frontal gyrus Top expressed in body of femur tibiofemoral joint cochlea fossa vestibular labyrinth vestibular sensory epithelium efferent ductule sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent protein binding extracellular matrix protein binding Cellular component extracellular region endoplasmic reticulum lumen extracellular matrix Biological process skeletal system development biomineral tissue development post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56955 94111 Ensembl ENSG00000152595 ENSMUSG00000053863 UniProt Q9NQ76 Q8K4L6 RefSeq (mRNA) NM_001184694 NM_001184695 NM_001184696 NM_001184697 NM_001291183 NM_020203 NM_053172 RefSeq (protein) NP_001171623 NP_001171624 NP_001171625 NP_001171626 NP_001278112 NP_064588 NP_444402 Location (UCSC) Chr 4: 87.82 – 87.85 Mb Chr 5: 104.47 – 104.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Osteoregulin
Identifiers
Symbol	Osteoregulin
Pfam	PF07175
InterPro	IPR009837
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

References

1. GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053863 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.
6. "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".
7. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

Further reading

• Quarles LD (2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization". Am. J. Physiol. Endocrinol. Metab. 285 (1): E1–9. doi:10.1152/ajpendo.00016.2003. PMID 12791601.
• Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
• Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. S2CID 17978869.
• Jain A, Fedarko NS, Collins MT, et al. (2004). "Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density". J. Clin. Endocrinol. Metab. 89 (8): 4158–61. doi:10.1210/jc.2003-032031. PMID 15292364.
• Nampei A, Hashimoto J, Hayashida K, et al. (2005). "Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone". J. Bone Miner. Metab. 22 (3): 176–84. doi:10.1007/s00774-003-0468-9. PMID 15108058. S2CID 13194013.
• MacDougall M, Simmons D, Gu TT, Dong J (2003). "MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21". Connect. Tissue Res. 43 (2–3): 320–30. doi:10.1080/713713461. PMID 12489176.
• Argiro L, Desbarats M, Glorieux FH, Ecarot B (2001). "Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone". Genomics. 74 (3): 342–51. doi:10.1006/geno.2001.6553. PMID 11414762.

This article incorporates text from the public domain Pfam and InterPro: IPR009837