Nandrolone decanoate
Anabolic steroid / From Wikipedia, the free encyclopedia
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Nandrolone decanoate, sold under the brand names Rolon[7] and Deca-Durabolin, among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.[8][9][10][11][4] It is given by injection into muscle or fat once every one to four weeks.[4][12]
Clinical data | |
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Trade names | Rolon, Deca-Durabolin, others |
Other names | • Nandrolone decylate • 19-Nortestosterone 17β-decanoate |
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Routes of administration | Intramuscular injection, subcutaneous injection |
Drug class | Androgen; Anabolic steroid; Androgen ester; Progestogen |
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Bioavailability | Intramuscular: 53–73%[1] |
Metabolism | Blood (hydrolysis), liver (reduction)[2][3] |
Metabolites | • Nandrolone[2][4] • 5α-Dihydronandrolone[2][4] • 19-Norandrosterone[2] • 19-Noretiocholanolone[2] • Conjugates[3] |
Elimination half-life | • Intramuscular: 6–12 days[2][5] • Nandrolone: <4.3 hours[2] |
Duration of action | • Intramuscular: 2–3 weeks[4][6] |
Excretion | Urine[2] |
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ECHA InfoCard | 100.006.037 |
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Formula | C28H44O3 |
Molar mass | 428.657 g·mol−1 |
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Side effects of nandrolone decanoate may include symptoms of masculinization like acne, increased hair growth, and voice changes.[4] The medication is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[4][13] It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women and children.[4][13][14] Nandrolone decanoate is a nandrolone ester and a long-lasting prodrug of nandrolone in the body.[4][15]
Nandrolone decanoate was first described in 1960 and was introduced for medical use in 1962.[4] It was the second nandrolone ester to be introduced, following nandrolone phenylpropionate (NPP) in 1959, and is one of the most widely used nandrolone esters.[4][16] It is also one of the most widely used AAS worldwide.[4] In addition to its medical use, nandrolone decanoate is used to improve physique and performance, and is said to be the most widely used AAS for such purposes.[4][17] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[4]