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Androgen receptor
Mammalian protein found in humans / From Wikipedia, the free encyclopedia
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The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor[9] that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone,[10] in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.[11][12]
Androgen_recep | |||||||||
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![]() crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor nh2-terminal peptide, ar20-30, and r1881 | |||||||||
Identifiers | |||||||||
Symbol | Androgen_recep | ||||||||
Pfam | PF02166 | ||||||||
InterPro | IPR001103 | ||||||||
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Human_androgen_receptor_and_androgen_binding.svg/640px-Human_androgen_receptor_and_androgen_binding.svg.png)
The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression;[13] however, the androgen receptor has other functions as well.[14] Androgen-regulated genes are critical for the development and maintenance of the male sexual phenotype.