Lindane
Organochlorine chemical and an isomer of hexachlorocyclohexane / From Wikipedia, the free encyclopedia
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Lindane, also known as gamma-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC),[3] is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies.[4][5]
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AHFS/Drugs.com | Monograph |
MedlinePlus | a682651 |
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Routes of administration | Topical |
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Protein binding | 91% |
Metabolism | Hepatic cytochrome P-450 oxygenase system |
Elimination half-life | 18 hours |
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ECHA InfoCard | 100.000.365 |
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Formula | C6H6Cl6 |
Molar mass | 290.81 g·mol−1 |
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Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. In humans, lindane affects the nervous system, liver, and kidneys, and may well be a carcinogen.[6][7] Whether lindane is an endocrine disruptor is unclear.[8][9][10]
The World Health Organization classifies lindane as "moderately hazardous", and its international trade is restricted and regulated under the Rotterdam Convention on Prior Informed Consent.[11] In 2009, the production and agricultural use of lindane was banned under the Stockholm Convention on persistent organic pollutants.[2][12] A specific exemption to that ban allows it to continue to be used as a second-line pharmaceutical treatment for lice and scabies.[13]