KAT7 (gene)
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene.[5][6][7] It specifically acetylates H4 histones at the lysine12 residue (H4K12)[8] and is necessary for origin licensing and DNA replication.[9][10] KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1.[11] Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.[12]
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