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DNA re-replication
Undesirable occurrence in eukaryotic cells / From Wikipedia, the free encyclopedia
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DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more than once per cell cycle.[1] Rereplication is believed to lead to genomic instability and has been implicated in the pathologies of a variety of human cancers.[2] To prevent rereplication, eukaryotic cells have evolved multiple, overlapping mechanisms to inhibit chromosomal DNA from being partially or fully rereplicated in a given cell cycle. These control mechanisms rely on cyclin-dependent kinase (CDK) activity.[1] DNA replication control mechanisms cooperate to prevent the relicensing of replication origins and to activate cell cycle and DNA damage checkpoints.[2] DNA rereplication must be strictly regulated to ensure that genomic information is faithfully transmitted through successive generations.
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