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Dihydropyrimidine dehydrogenase (NADP+)
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In enzymology, a dihydropyrimidine dehydrogenase (NADP+) (EC 1.3.1.2) is an enzyme that catalyzes the chemical reaction
- 5,6-dihydrouracil + NADP+
uracil + NADPH + H+
Quick Facts Identifiers, EC no. ...
dihydropyrimidine dehydrogenase (NADP+) | |||||||||
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![]() Dihydroprymidine dehydrogenase dimer, Sus scrofa | |||||||||
Identifiers | |||||||||
EC no. | 1.3.1.2 | ||||||||
CAS no. | 9029-01-0 | ||||||||
Alt. names | Dihydrothymine dehydrogenase | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NADP+, whereas its 3 products are uracil, NADPH, and H+.
In humans the enzyme is encoded by the DPYD gene.[1][2] It is the initial and rate-limiting step in pyrimidine catabolism.[citation needed] It catalyzes the reduction of uracil and thymine.[3] It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur.[4] It also participates in beta-alanine metabolism and pantothenate and coa biosynthesis.