Desmethylprodine
Opioid analgesic drug / From Wikipedia, the free encyclopedia
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Desmethylprodine or 1-methyl-4-phenyl-4-propionoxypiperidine (MPPP, Ro 2-0718) is an opioid analgesic drug developed in the 1940s by researchers at Hoffmann-La Roche.[1] Desmethylprodine has been labeled by the DEA as a Schedule I drug in the United States. It is an analog of pethidine (meperidine) a Schedule II drug. Chemically, it is a reversed ester of pethidine which has about 70% of the potency of morphine. Unlike its derivative prodine, it does not exhibit optical isomerism.[2] It was reported to have 30 times the activity of pethidine and a greater analgesic effect than morphine in rats, and it was demonstrated to cause central nervous system stimulation in mice.[2]
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Other names | 4-propionyloxy-4-phenyl-N-methylpiperidine, MPPP, 3-desmethylprodine |
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Formula | C15H21NO2 |
Molar mass | 247.338 g·mol−1 |
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