DYNC1I1

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.^[5][6][7]

DYNC1I1
Identifiers
Aliases	DYNC1I1, dynein, cytoplasmic 1, intermediate chain 1, DNCI1, DNCIC1, dynein cytoplasmic 1 intermediate chain 1
External IDs	OMIM: 603772; MGI: 107743; HomoloGene: 68398; GeneCards: DYNC1I1; OMA:DYNC1I1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 95,772,506 bp[1] End 96,110,322 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A1|6 2.26 cM Start 5,725,639 bp[2] End 6,028,039 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Pons pars compacta middle temporal gyrus frontal pole superior vestibular nucleus cerebellar vermis pars reticulata Brodmann area 23 lateral nuclear group of thalamus Top expressed in pontine nuclei ventral tegmental area Medulla Oblongata medial vestibular nucleus dorsal tegmental nucleus perirhinal cortex deep cerebellar nuclei lobe of cerebellum barrel cortex dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity spectrin binding microtubule binding protein binding cytoskeletal motor activity plus-end-directed microtubule motor activity dynein light chain binding dynein heavy chain binding Cellular component cytoplasm recycling endosome vesicle cytosol spindle pole chromosome perinuclear region of cytoplasm dynein complex cytoplasmic ribonucleoprotein granule microtubule chromosome, centromeric region cytoskeleton nucleus kinetochore cytoplasmic dynein complex Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II vesicle transport along microtubule endoplasmic reticulum to Golgi vesicle-mediated transport microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1780 13426 Ensembl ENSG00000158560 ENSMUSG00000029757 UniProt O14576 O88485 RefSeq (mRNA) NM_001135556 NM_001135557 NM_001278421 NM_001278422 NM_004411 NM_001191023 NM_001191025 NM_001191026 NM_001191027 NM_010063 RefSeq (protein) NP_001129028 NP_001129029 NP_001265350 NP_001265351 NP_004402 NP_001177952 NP_001177954 NP_001177955 NP_001177956 NP_034193 Location (UCSC) Chr 7: 95.77 – 96.11 Mb Chr 6: 5.73 – 6.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In melanocytic cells DYNC1I1 gene expression may be regulated by MITF.^[8]

Interactions

DYNC1I1 has been shown to interact with DYNLL1.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000158560 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029757 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
6. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
7. "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1".
8. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
9. Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50). United States: 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239.

Further reading

• King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. doi:10.1074/jbc.271.50.32281. PMID 8943288.
• Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
• Horikawa I, Parker ES, Solomon GG, Barrett JC (2001). "Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells". J. Cell. Biochem. 82 (3): 415–21. doi:10.1002/jcb.1169. PMID 11500918. S2CID 10899690.
• Karki S, Ligon LA, DeSantis J, et al. (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact". Mol. Biol. Cell. 13 (5): 1722–34. doi:10.1091/mbc.02-02-0011. PMC 111139. PMID 12006665.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ligon LA, Tokito M, Finklestein JM, et al. (2004). "A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity". J. Biol. Chem. 279 (18): 19201–8. doi:10.1074/jbc.M313472200. PMID 14985359.
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.
• Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMC 3857739. PMID 15992542.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.