Chromosome 18 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 18 spans about 80 million base pairs (the building material of DNA) and represents about 2.5 percent of the total DNA in cells.
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Number of genes
The following are some of the gene count estimates of human chromosome 18. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[4]
More information Estimated by, Protein-coding genes ...
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Gene list
The following is a partial list of genes on human chromosome 18. For complete list, see the link in the infobox on the right.
- ASXL3: encoding protein Additional sex combs like 3 (Drosophila)
- C18orf63: encoding protein Chromosome 18 open reading frame 63
- CABLES1: encoding protein CDK5 and ABL1 enzyme substrate 1
- CABYR: Calcium-binding tyrosine phosphorylation-regulated protein
- CHMP1B: Charged multivesicular body protein 1b
- CXXC1: CXXC-type zinc finger protein 1
- DCC: Deleted in Colorectal Cancer
- DIPK1C: encoding protein Divergent protein kinase domain 1C
- ELAC1: elaC ribonuclease Z 1
- ESCO1: encoding protein Establishment of sister chromatid cohesion N-acetyltransferase 1
- FECH: ferrochelatase (protoporphyria)
- GREB1L: encoding protein Growth regulation by estrogen in breast cancer-like
- HAUS1: HAUS augmin-like complex subunit 1
- HDHD2: encoding enzyme Haloacid dehalogenase-like hydrolase domain-containing protein 2
- IER3IP1: encoding protein Immediate early response 3-interacting protein 1
- MIR133A1: encoding microRNA MicroRNA 133a-1
- MIR187: encoding protein MicroRNA 187
- MRCL3: encoding protein Myosin regulatory light chain 12A
- NAPG: encoding protein Gamma-soluble NSF attachment protein
- NOL4: encoding protein Nucleolar protein 4
- NPC1: Niemann-Pick disease, type C1
- PIGN: encoding protein Phosphatidylinositol glycan anchor biosynthesis, class N
- PSTPIP2: encoding enzyme Proline-serine-threonine phosphatase-interacting protein 2
- RP11-267C16.1: non-coding
- SERPINB10: encoding protein Serpin peptidase inhibitor, clade B (ovalbumin), member 10
- SIGLEC15: encoding protein Sialic acid binding Ig-like lectin 15
- SMAD4: SMAD, mothers against DPP homolog 4 (Drosophila)
- TMEM241: encoding protein Transmembrane protein 241
- TTC39C: encoding protein Tetratricopeptide repeat protein 39C
- TWSG1: encoding protein Twisted gastrulation protein homolog 1
- ZCCHC2: encoding protein Zinc finger CCHC domain-containing protein 2
- ZFP161: encoding protein Zinc finger protein 161 homolog
- ZNF236: encoding protein Zinc finger protein 236
- ZNF516: encoding protein Zinc finger protein 516
- ZNF521: encoding protein Zinc finger protein 521
- ZNF532: encoding protein Zinc finger protein 532
The following diseases are some of those related to genes on chromosome 18:
G-banding ideogram of human chromosome 18 in resolution 850 bphs. Band length in this diagram is proportional to base-pair length. This type of ideogram is generally used in genome browsers (e.g.
Ensembl,
UCSC Genome Browser).
G-banding patterns of human chromosome 18 in three different resolutions (400,
[12] 550
[13] and 850
[3]). Band length in this diagram is based on the ideograms from ISCN (2013).
[14] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the
mitotic process.
[15]
More information Chr., Arm ...
G-bands of human chromosome 18 in resolution 850 bphs[16]
Chr. |
Arm[17] |
Band[18] |
ISCN start[19] |
ISCN stop[19] |
Basepair start |
Basepair stop |
Stain[20] |
Density |
18 | p |
11.32 | 0 | 159 | 1 | 2,900,000 |
gneg | |
18 | p |
11.31 | 159 | 430 | 2,900,001 | 7,200,000 |
gpos | 50 |
18 | p |
11.23 | 430 | 526 | 7,200,001 | 8,500,000 |
gneg | |
18 | p |
11.22 | 526 | 685 | 8,500,001 | 10,900,000 |
gpos | 25 |
18 | p |
11.21 | 685 | 1035 | 10,900,001 | 15,400,000 |
gneg | |
18 | p |
11.1 | 1035 | 1290 | 15,400,001 | 18,500,000 |
acen | |
18 | q |
11.1 | 1290 | 1561 | 18,500,001 | 21,500,000 |
acen | |
18 | q |
11.2 | 1561 | 1847 | 21,500,001 | 27,500,000 |
gneg | |
18 | q |
12.1 | 1847 | 2229 | 27,500,001 | 35,100,000 |
gpos | 100 |
18 | q |
12.2 | 2229 | 2436 | 35,100,001 | 39,500,000 |
gneg | |
18 | q |
12.3 | 2436 | 2755 | 39,500,001 | 45,900,000 |
gpos | 75 |
18 | q |
21.1 | 2755 | 3153 | 45,900,001 | 50,700,000 |
gneg | |
18 | q |
21.2 | 3153 | 3392 | 50,700,001 | 56,200,000 |
gpos | 75 |
18 | q |
21.31 | 3392 | 3519 | 56,200,001 | 58,600,000 |
gneg | |
18 | q |
21.32 | 3519 | 3663 | 58,600,001 | 61,300,000 |
gpos | 50 |
18 | q |
21.33 | 3663 | 3758 | 61,300,001 | 63,900,000 |
gneg | |
18 | q |
22.1 | 3758 | 4077 | 63,900,001 | 69,100,000 |
gpos | 100 |
18 | q |
22.2 | 4077 | 4204 | 69,100,001 | 71,000,000 |
gneg | |
18 | q |
22.3 | 4204 | 4411 | 71,000,001 | 75,400,000 |
gpos | 25 |
18 | q |
23 | 4411 | 4650 | 75,400,001 | 80,373,285 |
gneg | |
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"p": Short arm; "q": Long arm.
For cytogenetic banding nomenclature, see article locus.
These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.
- Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. Bibcode:2005Natur.437..551N. doi:10.1038/nature03983. PMID 16177791.
- Chen H, Wang N, Huo Y, Sklar P, MacKinnon DF, Potash JB, McMahon FJ, Antonarakis SE, DePaulo JR Jr, Ross CA, McInnis MG (2003). "Trapping and sequence analysis of 1138 putative exons from human chromosome 18". Mol Psychiatry. 8 (6): 619–23. doi:10.1038/sj.mp.4001288. PMID 12851638.
- Gilbert F (1997). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 18". Genet Test. 1 (1): 69–71. doi:10.1089/gte.1997.1.69. PMID 10464628.