CXXC1

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.^[5][6][7]

CXXC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QMB, 3QMC, 3QMD, 3QMG, 3QMH, 3QMI
Identifiers
Aliases	CXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1
External IDs	OMIM: 609150; MGI: 1921572; HomoloGene: 32221; GeneCards: CXXC1; OMA:CXXC1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 50,282,343 bp[1] End 50,287,839 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E2 Start 74,349,195 bp[2] End 74,354,567 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum body of pancreas right uterine tube pancreatic ductal cell granulocyte right lobe of thyroid gland skin of leg sural nerve skin of abdomen left lobe of thyroid gland Top expressed in Ileal epithelium tail of embryo genital tubercle neural layer of retina choroid plexus of fourth ventricle lactiferous gland entorhinal cortex perirhinal cortex secondary oocyte otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding protein binding cis-regulatory region sequence-specific DNA binding histone methyltransferase activity (H3-K4 specific) metal ion binding unmethylated CpG binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear matrix nuclear speck nucleus nucleoplasm histone methyltransferase complex cytosol Set1C/COMPASS complex Biological process positive regulation of transcription, DNA-templated IRE1-mediated unfolded protein response histone H3-K4 methylation regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30827 74322 Ensembl ENSG00000154832 ENSMUSG00000024560 UniProt Q9P0U4 Q9CWW7 RefSeq (mRNA) NM_001101654 NM_014593 NM_028868 NM_001378844 RefSeq (protein) NP_001095124 NP_055408 NP_083144 NP_001365773 Location (UCSC) Chr 18: 50.28 – 50.29 Mb Chr 18: 74.35 – 74.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.^[6]

See also

• PHD finger
• CXXC5

References

1. GRCh38: Ensembl release 89: ENSG00000154832 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024560 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun. 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
6. Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol. 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657.
7. "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)".

External links

• Human CXXC1 genome location and CXXC1 gene details page in the UCSC Genome Browser.
• Human SPP1 genome location and SPP1 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9P0U4 (CXXC-type zinc finger protein 1) at the PDBe-KB.

Further reading

• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Lee JH, Voo KS, Skalnik DG (2002). "Identification and characterization of the DNA binding domain of CpG-binding protein". J. Biol. Chem. 276 (48): 44669–44676. doi:10.1074/jbc.M107179200. PMID 11572867.
• Carlone DL, Skalnik DG (2001). "CpG binding protein is crucial for early embryonic development". Mol. Cell. Biol. 21 (22): 7601–7606. doi:10.1128/MCB.21.22.7601-7606.2001. PMC 99931. PMID 11604496.
• Lee JH, Skalnik DG (2003). "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals". J. Biol. Chem. 277 (44): 42259–42267. doi:10.1074/jbc.M205054200. PMID 12200428.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Lee JH, Skalnik DG (2006). "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex". J. Biol. Chem. 280 (50): 41725–41731. doi:10.1074/jbc.M508312200. PMID 16253997.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Young SR, Skalnik DG (2007). "CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line". DNA Cell Biol. 26 (2): 80–90. doi:10.1089/dna.2006.0535. PMID 17328666.