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4-Hydroxyphenylpyruvate dioxygenase
Fe(II)-containing non-heme oxygenase / From Wikipedia, the free encyclopedia
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4-Hydroxyphenylpyruvate dioxygenase (HPPD), also known as α-ketoisocaproate dioxygenase (KIC dioxygenase), is an Fe(II)-containing non-heme oxygenase that catalyzes the second reaction in the catabolism of tyrosine - the conversion of 4-hydroxyphenylpyruvate into homogentisate. HPPD also catalyzes the conversion of phenylpyruvate to 2-hydroxyphenylacetate and the conversion of α-ketoisocaproate to β-hydroxy β-methylbutyrate.[2][3] HPPD is an enzyme that is found in nearly all aerobic forms of life.[4]
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Quick Facts Identifiers, EC no. ...
4-hydroxyphenylpyruvate dioxygenase | |||||||||
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![]() Homodimer of 4-Hydroxyphenylpyruvate dioxygenase. Red ribbon represents iron-containing catalytic domain (with Fe 2+ represented as red-orange spheres); blue represents the oligomeric domain. Image generated from published structural data [1] | |||||||||
Identifiers | |||||||||
EC no. | 1.13.11.27 | ||||||||
CAS no. | 9029-72-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
4-hydroxyphenylpyruvate dioxygenase | |||||||
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Identifiers | |||||||
Symbol | HPPD | ||||||
Alt. symbols | HPD; PPD | ||||||
NCBI gene | 3242 | ||||||
HGNC | 5147 | ||||||
OMIM | 609695 | ||||||
RefSeq | NM_002150 | ||||||
UniProt | P32754 | ||||||
Other data | |||||||
EC number | 1.13.11.27 | ||||||
Locus | Chr. 12 q24-qter | ||||||
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