Protein sy'n cael ei godio yn y corff dynol gan y genyn AIRE yw AIRE a elwir hefyd yn Autoimmune regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.[2]
Ffeithiau sydyn Strwythurau, PDB ...
AIRE |
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Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Dynodwyr |
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Cyfenwau | AIRE, AIRE1, APECED, APS1, APSI, PGA1, autoimmune regulator |
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Dynodwyr allanol | OMIM: 607358 HomoloGene: 327 GeneCards: AIRE |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0031493 histone binding • chromatin binding • GO:0001104 transcription coregulator activity • translation regulator activity • metal ion binding • GO:0001948, GO:0016582 protein binding • identical protein binding • zinc ion binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Cydrannau o'r gell | • cytoplasm • intracellular anatomical structure • nuclear body • cnewyllyn cell
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Prosesau biolegol | • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • negative thymic T cell selection • humoral immune response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of translation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • peripheral T cell tolerance induction • central tolerance induction to self antigen • chemokine production • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • thymus epithelium morphogenesis • regulation of thymocyte migration
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Cau