RNH1

Inhibitor ribonukleaze je enzim koji je kod ljudi kodiran genom RNH1.^[5]

RNH1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1Z7X, 1A4Y, 2BEX, 2Q4G
Identifikatori
Aliasi	RNH1
Vanjski ID-jevi	OMIM: 173320 MGI: 1195456 HomoloGene: 2204 GeneCards: RNH1
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.5 Početak 494,512 bp[1] Kraj 507,300 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7|7 F5 Početak 140,740,239 bp[2] Kraj 140,752,770 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • ribonuclease inhibitor activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • angiogenin-PRI complex • Egzosom • nukleoplazma • citoplazma • citosol Biološki proces • regulation of angiogenesis • mRNA catabolic process • GO:0048553 negative regulation of catalytic activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6050	107702
Ensembl	ENSG00000276230 ENSG00000023191	ENSMUSG00000038650
UniProt	P13489	Q91VI7
RefSeq (mRNK)	NM_002939 NM_203383 NM_203384 NM_203385 NM_203386 NM_203387 NM_203388 NM_203389	NM_001172100 NM_001172101 NM_145135
RefSeq (bjelančevina)	NP_002930 NP_976317 NP_976318 NP_976319 NP_976320 NP_976321 NP_976322 NP_976323	NP_001165571 NP_001165572 NP_660117
Lokacija (UCSC)	Chr 11: 0.49 – 0.51 Mb	Chr 7: 140.74 – 140.75 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 461 aminokiselina, a molekulska težina 49.973 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSLDIQSLDI		QCEELSDARW		AELLPLLQQC		QVVRLDDCGL		TEARCKDISS
ALRVNPALAE		LNLRSNELGD		VGVHCVLQGL		QTPSCKIQKL		SLQNCCLTGA
GCGVLSSTLR		TLPTLQELHL		SDNLLGDAGL		QLLCEGLLDP		QCRLEKLQLE
YCSLSAASCE		PLASVLRAKP		DFKELTVSNN		DINEAGVRVL		CQGLKDSPCQ
LEALKLESCG		VTSDNCRDLC		GIVASKASLR		ELALGSNKLG		DVGMAELCPG
LLHPSSRLRT		LWIWECGITA		KGCGDLCRVL		RAKESLKELS		LAGNELGDEG
ARLLCETLLE		PGCQLESLWV		KSCSFTAACC		SHFSSVLAQN		RFLLELQISN
NRLEDAGVRE		LCQGLGQPGS		VLRVLWLADC		DVSDSSCSSL		AATLLANHSL
RELDLSNNCL		GDAGILQLVE		SVRQPGCLLE		QLVLYDIYWS		EEMEDRLQAL
EKDKPSLRVI		S

Reference

1. ENSG00000023191 GRCh38: Ensembl release 89: ENSG00000276230, ENSG00000023191 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038650 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1".
6. "UniProt, P13489". Pristupljeno 26. 8. 2021.

Dopunska literatura

• Zneimer SM, Crawford D, Schneider NR, Beutler B (1991). "Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization". Genomics. 8 (1): 175–8. doi:10.1016/0888-7543(90)90242-M. PMID 2081593.
• Weremowicz S, Fox EA, Morton CC, Vallee BL (1991). "The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5". Genomics. 8 (4): 717–21. doi:10.1016/0888-7543(90)90260-2. PMID 2276743.
• Lee FS, Vallee BL (1989). "Binding of placental ribonuclease inhibitor to the active site of angiogenin". Biochemistry. 28 (8): 3556–61. doi:10.1021/bi00434a061. PMID 2742853.
• Bond MD, Vallee BL (1989). "Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay". Biochemistry. 27 (17): 6282–7. doi:10.1021/bi00417a013. PMID 3064806.
• Hofsteenge J, Kieffer B, Matthies R, et al. (1989). "Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats". Biochemistry. 27 (23): 8537–44. doi:10.1021/bi00423a006. PMID 3219361.
• Lee FS, Fox EA, Zhou HM, et al. (1989). "Primary structure of human placental ribonuclease inhibitor". Biochemistry. 27 (23): 8545–53. doi:10.1021/bi00423a007. PMID 3219362.
• Schneider R, Schneider-Scherzer E, Thurnher M, et al. (1989). "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module". EMBO J. 7 (13): 4151–6. doi:10.1002/j.1460-2075.1988.tb03310.x. PMC 455125. PMID 3243277.
• Shapiro R, Vallee BL (1987). "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2238–41. doi:10.1073/pnas.84.8.2238. PMC 304624. PMID 3470787.
• Kiyohara H, Menjo M (1984). "Ribonuclease and ribonuclease inhibitor in the human pancreas". Gastroenterol. Jpn. 18 (5): 468–73. doi:10.1007/BF02776587. PMID 6653993. S2CID 10963236.
• Nadano D, Yasuda T, Takeshita H, et al. (1994). "Purification and characterization of human brain ribonuclease inhibitor". Arch. Biochem. Biophys. 312 (2): 421–8. doi:10.1006/abbi.1994.1328. PMID 8037455.
• Kobe B, Deisenhofer J (1994). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats". Nature. 366 (6457): 751–6. doi:10.1038/366751a0. PMID 8264799. S2CID 34579479.
• Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977.
• Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fu P, Chen J, Tian Y, et al. (2005). "Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor". Cancer Gene Ther. 12 (3): 268–75. doi:10.1038/sj.cgt.7700742. PMID 15592448.
• Iyer S, Holloway DE, Kumar K, et al. (2005). "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor". J. Mol. Biol. 347 (3): 637–55. doi:10.1016/j.jmb.2005.01.035. PMID 15755456.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Johnson RJ, McCoy JG, Bingman CA, et al. (2007). "Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein". J. Mol. Biol. 368 (2): 434–49. doi:10.1016/j.jmb.2007.02.005. PMC 1993901. PMID 17350650.

Vanjski linkovi