T-boksni transkripcijski faktor TBX3 jest protein koji je kod ljudi kodiran genom TBX3.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
TBX3 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/c/ce/Protein_TBX3_PDB_1h6f.png/250px-Protein_TBX3_PDB_1h6f.png) |
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Identifikatori |
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Aliasi | TBX3 |
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Vanjski ID-jevi | OMIM: 601621 MGI: 98495 HomoloGene: 4371 GeneCards: TBX3 |
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Ontologija gena |
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Molekularna funkcija | • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • jedro
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Biološki proces | • forelimb morphogenesis • Ćelijsko starenje • branching involved in mammary gland duct morphogenesis • positive regulation of stem cell proliferation • atrioventricular bundle cell differentiation • negative regulation of epithelial cell differentiation • female genitalia development • transcription, DNA-templated • male genitalia development • multicellular organism development • anterior/posterior axis specification, embryo • outflow tract morphogenesis • skeletal system development • ventricular septum morphogenesis • embryonic forelimb morphogenesis • cardiac muscle cell fate commitment • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • heart morphogenesis • regulation of cell population proliferation • heart looping • negative regulation of myoblast differentiation • specification of animal organ position • stem cell population maintenance • luteinizing hormone secretion • follicle-stimulating hormone secretion • blood vessel development • positive regulation of cell population proliferation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • roof of mouth development • mammary placode formation • in utero embryonic development • mesoderm morphogenesis • GO:0009373 regulation of transcription, DNA-templated • limb morphogenesis • sinoatrial node cell development • positive regulation of cell cycle • cardiac muscle cell differentiation • limbic system development • embryonic hindlimb morphogenesis • animal organ morphogenesis • embryonic heart tube development • embryonic digit morphogenesis • mammary gland development • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of apoptotic process
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 12: 114.67 – 114.68 Mb | Chr 5: 119.81 – 119.82 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
T-boks 3 (TBX3) je član porodice gena T-kutije transkripcijskih faktora koji svi dijele visoko konzervirani domen vezanja za DNK poznat kao T-kutija. Porodica gena ove kutije sastoji se od 17 članova kod miševa i ljudi, koji su grupirani u pet potporodica, i to Brachyury (T), T-moždana (Tbr1), TBX1, TBX2 i TBX6. Tbx3 je član potporodice Tbx2 koja uključuje Tbx2, Tbx4 i Tbx5.[7] Ljudski gen TBX3 nalazi se u hromosomu 12, na poziciji 12q23-24.1 i sastoji se od sedam egzon koji kodiraju protein od 723 aminokiseline (prema ENSEMBL, sklop GRCh38.p12).