Runt-srodni transkripcijski faktor 1 (RUNX1), znan i kao protein 1 akutne mijeloidne leukemije (AML1) ili podjedinica alfa-2 jezgarno vezanog faktora (CBFA2) jest protein koji je kod ljudi kodiran genom RUNX1 sa hromosoma 21.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
RUNX1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/33/PDB_1cmo_EBI.jpg/250px-PDB_1cmo_EBI.jpg) |
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Identifikatori |
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Aliasi | RUNX1 |
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Vanjski ID-jevi | OMIM: 151385 MGI: 99852 HomoloGene: 1331 GeneCards: RUNX1 |
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Ontologija gena |
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Molekularna funkcija | • vezivanje sa DNK • calcium ion binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0001948, GO:0016582 vezivanje za proteine • protein heterodimerization activity • ATP binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Ćelijska komponenta | • intracellular membrane-bounded organelle • jedro • citosol • nukleoplazma • core-binding factor complex
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Biološki proces | • peripheral nervous system neuron development • myeloid cell differentiation • GO:0009373 regulation of transcription, DNA-templated • chondrocyte differentiation • ossification • negative regulation of granulocyte differentiation • hematopoietic stem cell proliferation • transcription, DNA-templated • positive regulation of angiogenesis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of interleukin-2 production • positive regulation of granulocyte differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • regulation of cytokine-mediated signaling pathway • regulation of Wnt signaling pathway • regulation of intracellular estrogen receptor signaling pathway • regulation of regulatory T cell differentiation • regulation of keratinocyte differentiation • regulation of myeloid cell differentiation • regulation of megakaryocyte differentiation • regulation of B cell receptor signaling pathway • regulation of hematopoietic stem cell differentiation • regulation of bicellular tight junction assembly • Hematopoeza • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of CD4-positive, alpha-beta T cell differentiation • positive regulation of CD8-positive, alpha-beta T cell differentiation • negative regulation of gene expression • neuron differentiation
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 21: 34.79 – 36 Mb | Chr 16: 92.4 – 92.62 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori