RPS4Y1

40S ribosomski protein S4, Y izoforma 1 je protein koji je kod ljudi kodiran genom RPS4Y1.^[5][6][7]

RPS4Y1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 5AJ0, 5FLX, 4D61, 4D5L, 4UJD, 4UJE, 4UJC
Identifikatori
Aliasi	RPS4Y1
Vanjski ID-jevi	OMIM: 470000 MGI: 98158 HomoloGene: 133576 GeneCards: RPS4Y1
Lokacija gena (čovjek) Hrom. Hromosom Y[1] Bend Yp11.2 Početak 2,841,602 bp[1] Kraj 2,932,000 bp[1]
Lokacija gena (miš) Hrom. Hromosom X (miš)[2] Bend X D|X 45.2 cM Početak 101,228,547 bp[2] Kraj 101,233,000 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • rRNA binding • structural constituent of ribosome • RNA binding Ćelijska komponenta • ribozom • polysome • citosol • Jedro • membrana • intracellular anatomical structure • Nukleoplazma • cytosolic small ribosomal subunit Biološki proces • SRP-dependent cotranslational protein targeting to membrane • viral transcription • multicellular organism development • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translational initiation • Biosinteza bjelančevina • rRNA processing Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6192	20102
Ensembl	ENSG00000129824	ENSMUSG00000031320
UniProt	P22090	P62702
RefSeq (mRNK)	NM_001008	NM_009094
RefSeq (bjelančevina)	NP_000999	NP_033120
Lokacija (UCSC)	Chr Y: 2.84 – 2.93 Mb	Chr X: 101.23 – 101.23 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Citoplazmatski ribosomi, organele koje kataliziraju sintezu proteina, sastoje se od male 40S i velike 60S podjedinice. Zajedno se ove podjedinice sastoje od četiti tipa molekula RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomski protein S4, komponentu podjedinice 40S. Ribosomski protein S4 jedini je ribosomski protein za koji je poznato da ga kodira više od jednog gena. To su ovaj gen, RPS4Y2 i ribosomski protein S4, X-vezani (RPS4X).Tri izoforme kodirane ovim genima nisu identične, ali izgleda da su funkcijski ekvivalenti.^[8] Ribosomski protein S4 pripada porodici S4E ribosomskih proteina. Sugerira se da haploinsuficijencija gena ribosomskog proteina S4 ima ulogu u Turnerovom sindromu; ova hipoteza je, međutim, kontroverzna.^[5]

Također pogledajte

• Domen proteina S4

Reference

1. GRCh38: Ensembl release 89: ENSG00000129824 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031320 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1".
6. Fisher EM, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Lawrence JB, Willard HF, Bieber FR, Page DC (decembar 1990). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome". Cell. 63 (6): 1205–18. doi:10.1016/0092-8674(90)90416-C. PMID 2124517.
7. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (maj 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
8. Andrés O, Kellermann T, López-Giráldez F, Rozas J, Domingo-Roura X, Bosch M (2008). "RPS4Y gene family evolution in primates". BMC Evol. Biol. 8: 142. doi:10.1186/1471-2148-8-142. PMC 2397393. PMID 18477388.

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