Tetrahydrofuran
Cyclic chemical compound, (CH₂)₄O / From Wikipedia, the free encyclopedia
"THF" redirects here. For other uses, see THF (disambiguation).
Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers.[8] Being polar and having a wide liquid range, THF is a versatile solvent. It is an isomer of another solvent, butanone.
Quick Facts Names, Identifiers ...
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Names | |||
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Preferred IUPAC name
Oxolane[1] | |||
Systematic IUPAC name
1,4-Epoxybutane 1-Oxacyclopentane | |||
Other names
Tetrahydrofuran THF 1,4-Butylene oxide Cyclotetramethylene oxide fraction Furanidin Tetra-methylene oxide, Oxolane | |||
Identifiers | |||
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3D model (JSmol) |
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Abbreviations | THF | ||
ChEBI | |||
ChEMBL | |||
ChemSpider |
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ECHA InfoCard | 100.003.389 | ||
PubChem CID |
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RTECS number |
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UNII | |||
CompTox Dashboard (EPA) |
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Properties | |||
C4H8O | |||
Molar mass | 72.107 g·mol−1 | ||
Appearance | Colorless liquid | ||
Odor | Ether-like[2] | ||
Density | 0.8876 g/cm3 at 20 °C, liquid [3] | ||
Melting point | −108.4 °C (−163.1 °F; 164.8 K) | ||
Boiling point | 66 °C (151 °F; 339 K)[4][3] | ||
Miscible | |||
Vapor pressure | 132 mmHg (20 °C)[2] | ||
Refractive index (nD) |
1.4073 (20 °C) [3] | ||
Viscosity | 0.48 cP at 25 °C | ||
Structure | |||
Envelope | |||
1.63 D (gas) | |||
Hazards | |||
GHS labelling: | |||
[5] | |||
Danger | |||
H225, H302, H319, H335, H351[5] | |||
P210, P280, P301+P312+P330, P305+P351+P338, P370+P378, P403+P235[5] | |||
NFPA 704 (fire diamond) | |||
Flash point | −14 °C (7 °F; 259 K) | ||
Explosive limits | 2–11.8%[2] | ||
Lethal dose or concentration (LD, LC): | |||
LD50 (median dose) |
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LC50 (median concentration) |
21000 ppm (rat, 3 h)[6] | ||
NIOSH (US health exposure limits): | |||
PEL (Permissible) |
TWA 200 ppm (590 mg/m3)[2] | ||
REL (Recommended) |
TWA 200 ppm (590 mg/m3) ST 250 ppm (735 mg/m3)[2] | ||
IDLH (Immediate danger) |
2000 ppm[2] | ||
Related compounds | |||
Related heterocycles |
Furan Pyrrolidine Dioxane | ||
Related compounds |
Diethyl ether | ||
Supplementary data page | |||
Tetrahydrofuran (data page) | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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