马山茶碱(英语:Tabernanthine)是一种在鹅花树中发现的生物碱。[1]它已被用于实验室实验,以研究成瘾如何影响大脑。[2]马山茶碱可持续减少大鼠可卡因和吗啡的自我给药。[3]
事实速览 臨床資料, ATC碼 ...
马山茶碱 |
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ATC碼 | |
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(1R,15R,17S,18S)-17-ethyl-6-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene
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CAS号 | 83-94-3 |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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CompTox Dashboard (EPA) | |
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化学式 | C20H26N2O |
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摩尔质量 | 310.44 g·mol−1 |
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3D模型(JSmol) | |
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CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=CC(=C5)OC
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InChI=1S/C20H26N2O/c1-3-13-8-12-9-17-19-16(6-7-22(11-12)20(13)17)15-5-4-14(23-2)10-18(15)21-19/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3/t12-,13+,17+,20+/m1/s1 Key:UCIDWKVIQZIKEK-CFDPKNGZSA-N
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关闭
它是κ-阿片激动剂(Ki=0.15μM)和NMDA受体(Ki=10.5μM)拮抗剂。[4][5]与伊波加因相比,它与σ1和σ2受体的结合较弱。[5]
- 冠狗牙花定碱
- 依波加明
- 伏康京碱
- 山辣椒碱
- Tabernanthalog
Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine. Journal of the American Chemical Society. 1958, 80: 126–136. doi:10.1021/ja01534a036.
Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW, Carlson JN. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research. September 1994, 657 (1–2): 14–22. PMID 7820611. S2CID 1940631. doi:10.1016/0006-8993(94)90948-2.