异硫氰酸苄酯

异硫氰酸苄酯 (BITC) 是一种异硫氰酸酯，存在于十字花科的植物中。

事实速览 异硫氰酸苄酯, 识别 ...

异硫氰酸苄酯

IUPAC名
(Isothiocyanatomethyl)benzene

识别

性质

C₈H₇NS

149.21 g·mol⁻¹

1.125 g/mL^[1]

242-243℃^[1]

若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

关闭

活性

人们发现异硫氰酸苄酯和其他异硫氰酸酯通常通过p21/WAF1（英语：p21/WAF1）基因的表达，^[3]对in vitro的胰腺癌变具有保护作用。^[4]最近发表的一项研究表明，它对饮食诱导的肥胖小鼠模型中的肥胖、脂肪肝和胰岛素抵抗有抑制作用。^[5]

参考资料

[1]
Benzyl isothiocyanate. Sigma-Aldrich.
[2]
Nakamura, Yoshimasa; Yoshimoto, Motoko; Murata, Yoshiyuki; Shimoishi, Yasuaki; Asai, Yumi; Park, Eun Young; Sato, Kenji; Nakamura, Yasushi. Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate. Journal of Agricultural and Food Chemistry. 2007, 55 (11): 4407–13. PMID 17469845. doi:10.1021/jf070159w.
[3]
Moon, Sung-Kwon; Choi, Yung-Hyun; Kim, Cheorl-Ho; Choi, Won-Seok. P38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1. Biochemical and Biophysical Research Communications. 2006, 350 (3): 662–8. PMID 17026958. doi:10.1016/j.bbrc.2006.09.092.
[4]
Kuroiwa, Yuichi; Nishikawa, Akiyoshi; Kitamura, Yasuki; Kanki, Keita; Ishii, Yuji; Umemura, Takashi; Hirose, Masao. Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Letters. 2006, 241 (2): 275–80. PMID 16386831. doi:10.1016/j.canlet.2005.10.028.
[5]
Alsanea, Sary; Liu, Dexi. BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. Pharmaceutical Research. November 2017, 34 (11): 2241–2249 [2021-10-18]. ISSN 1573-904X. PMC 5757875 . PMID 28733781. doi:10.1007/s11095-017-2230-3. （原始内容存档于2019-12-26）.

这是一篇有關芳香化合物的小作品。您可以通过编辑或修订扩充其内容。

[1]
Benzyl isothiocyanate. Sigma-Aldrich.
[2]
Nakamura, Yoshimasa; Yoshimoto, Motoko; Murata, Yoshiyuki; Shimoishi, Yasuaki; Asai, Yumi; Park, Eun Young; Sato, Kenji; Nakamura, Yasushi. Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate. Journal of Agricultural and Food Chemistry. 2007, 55 (11): 4407–13. PMID 17469845. doi:10.1021/jf070159w.
[3]
Moon, Sung-Kwon; Choi, Yung-Hyun; Kim, Cheorl-Ho; Choi, Won-Seok. P38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1. Biochemical and Biophysical Research Communications. 2006, 350 (3): 662–8. PMID 17026958. doi:10.1016/j.bbrc.2006.09.092.
[4]
Kuroiwa, Yuichi; Nishikawa, Akiyoshi; Kitamura, Yasuki; Kanki, Keita; Ishii, Yuji; Umemura, Takashi; Hirose, Masao. Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Letters. 2006, 241 (2): 275–80. PMID 16386831. doi:10.1016/j.canlet.2005.10.028.
[5]
Alsanea, Sary; Liu, Dexi. BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. Pharmaceutical Research. November 2017, 34 (11): 2241–2249 [2021-10-18]. ISSN 1573-904X. PMC 5757875 . PMID 28733781. doi:10.1007/s11095-017-2230-3. （原始内容存档于2019-12-26）.

这是一篇有關芳香化合物的小作品。您可以通过编辑或修订扩充其内容。

存在