CGP-7930（化学名： 2,6-二叔丁基-4-(3-羟基-2,2-二甲基丙基)-苯酚，2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol）是一种有机化合物，是GABAB受体的正向别构调节剂，其作用效果和其同系物BSPP类似[1][2][3][4]。
事实速览 识别信息, CAS号 ...
CGP-7930 |
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2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol
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| CAS号 | 57717-80-3  Y |
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| 化学式 | C19H32O2 |
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| 摩尔质量 | 292.46 g·mol−1 |
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| 3D模型（JSmol） | |
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CC(C)(C)c1cc(CC(C)(C)CO)cc(C(C)(C)C)c1O
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InChI=1S/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3  NKey:XLWJPQQFJNGUPA-UHFFFAOYSA-N N
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关闭
Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology. November 2001, 60 (5): 963–71. PMID 11641424. Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. The Journal of Biological Chemistry. July 2004, 279 (28): 29085–91. PMID 15126507. doi:10.1074/jbc.M400930200 
. Chen Y, Menendez-Roche N, Sher E. Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. The Journal of Pharmacology and Experimental Therapeutics. June 2006, 317 (3): 1170–7. PMID 16507713. doi:10.1124/jpet.105.099176.
