ABT-418

ABT-418是一种有机化合物，化学式为C₉H₁₄N₂O，由美國雅培开发，可用作益智藥和抗焦慮藥。^{[1][2][3][4][5]}

ABT-418

识别信息
IUPAC命名法 3-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole
CAS号	147402-53-7  Y
PubChem CID	119380
ChemSpider	106627 Y
UNII	B9I6MZL7BW
ChEMBL	ChEMBL274525 Y
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID10163711
化学信息
化学式	C9H14N2O
摩尔质量	166.22
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC1=NOC(=C1)[C@@H]2CCCN2C
InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1 Y Key:ILLGYRJAYAAAEW-QMMMGPOBSA-N Y

参考文献

1. Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 310–318 [2023-11-09]. PMID 7518514. （原始内容存档于2005-05-07）.
2. Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 319–328 [2023-11-09]. PMID 7913497. （原始内容存档于2005-05-07）.
3. Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. The Journal of Pharmacology and Experimental Therapeutics. October 1994, 271 (1): 353–361 [2023-11-09]. PMID 7965735. （原始内容存档于2009-09-05）.
4. Prendergast MA, Terry AV, Jackson WJ, Marsh KC, Decker MW, Arneric SP, Buccafusco JJ. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418. Psychopharmacology. April 1997, 130 (3): 276–284. PMID 9151363. S2CID 34377165. doi:10.1007/s002130050240.
5. Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, et al. Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. European Journal of Medicinal Chemistry. December 2010, 45 (12): 5594–5601. PMID 20932609. doi:10.1016/j.ejmech.2010.09.009.

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