白细胞介素-7

白细胞介素-7（英語：Interleukin 7，缩写IL-7）是一种由人类基因 IL7 编码的蛋白质^[5]，主要由骨髓和胸腺中的基质细胞分泌^[6][7][8]，角质形成细胞^[9]、樹突狀細胞^[10]、肝細胞^[11]、神經元、上皮組織^[12]也会产生该因子，但正常淋巴细胞不会产生该因子^[13]。

白细胞介素-7与相关信号传导蛋白

白细胞介素-7
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 3DI2、​3DI3
識別號
别名	IL7；, IL-7, interleukin 7
外部ID	OMIM：146660 MGI：96561 HomoloGene：680 GeneCards：IL7
基因位置（人类） 染色体 8號染色體[1] 基因座 8q21.13 起始 78,675,743 bp[1] 终止 78,805,523 bp[1]
基因位置（小鼠） 染色体 小鼠3号染色体[2] 基因座 3 A1|3 2.02 cM 起始 7,635,054 bp[2] 终止 7,678,820 bp[2]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • 血浆蛋白结合 • interleukin-7 receptor binding • 生長因子活性 • 細胞因子受體結合 • 細胞因子活性 細胞組分 • 細胞外空間 • 細胞外區域 • collagen-containing extracellular matrix 生物學過程 • negative regulation of catalytic activity • cell-cell signaling • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of organ growth • negative regulation of apoptotic process • 骨质吸收 • humoral immune response • 免疫反应 • positive regulation of cell population proliferation • animal organ morphogenesis • 基因調節 • homeostasis of number of cells within a tissue • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • T cell lineage commitment • positive regulation of B cell proliferation • positive regulation of T cell differentiation • interleukin-7-mediated signaling pathway • regulation of signaling receptor activity • positive regulation of cytokine-mediated signaling pathway • cytokine-mediated signaling pathway • positive regulation of chemokine production • regulation of peptidyl-tyrosine phosphorylation • positive regulation of gene expression • positive regulation of B cell differentiation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3574	16196
Ensembl	ENSG00000104432	ENSMUSG00000040329
UniProt	P13232	P10168
mRNA​序列	​NM_000880 ​NM_001199886 ​NM_001199887 ​NM_001199888	NM_008371 ​NM_001313888 ​NM_001313889 ​NM_001313890
蛋白序列	NP_000871 ​NP_001186815 ​NP_001186816 ​NP_001186817	NP_001300817 ​NP_001300818 ​NP_001300819 ​NP_032397
基因位置​（UCSC）	Chr 8: 78.68 – 78.81 Mb	Chr 3: 7.64 – 7.68 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

参考文献

1. GRCh38: Ensembl release 89: ENSG00000104432 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040329 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. June 1988, 333 (6173): 571–3. Bibcode:1988Natur.333..571N. PMID 3259677. S2CID 4315541. doi:10.1038/333571a0.
6. Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc. Natl. Acad. Sci. U.S.A. January 1989, 86 (1): 302–6. Bibcode:1989PNAS...86..302G. PMC 286452 . PMID 2643102. doi:10.1073/pnas.86.1.302 .
7. Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA. The gene for human interleukin 7 (IL7) is at 8q12-13. Hum. Genet. July 1989, 82 (4): 371–2. PMID 2786840. S2CID 30870920. doi:10.1007/BF00274000.
8. Lupton SD, Gimpel S, Jerzy R, et al. Characterization of the human and murine IL-7 genes. J. Immunol. 1990, 144 (9): 3592–601. PMID 2329282. S2CID 36007598. doi:10.4049/jimmunol.144.9.3592 .
9. Heufler C, Topar G, Grasseger A, et al. Interleukin 7 is produced by murine and human keratinocytes. J. Exp. Med. September 1993, 178 (3): 1109–14. PMC 2191157 . PMID 8350050. doi:10.1084/jem.178.3.1109.
10. Kröncke R, Loppnow H, Flad HD, Gerdes J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur. J. Immunol. October 1996, 26 (10): 2541–4. PMID 8898972. S2CID 20992591. doi:10.1002/eji.1830261040.
11. Sawa Y, Arima Y, Ogura H, et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity. March 2009, 30 (3): 447–57. PMID 19285437. doi:10.1016/j.immuni.2009.01.007 .
12. Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 1995, 95 (6): 2945–53. PMC 295983 . PMID 7769137. doi:10.1172/JCI118002.
13. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood. June 2002, 99 (11): 3892–904. PMID 12010786. doi:10.1182/blood.V99.11.3892 .

外部链接