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来自维基百科,自由的百科全书
血小板衍生生長因子受體(Platelet-derived growth factor receptors,PDGF-R)為血小板衍生生長因子(PDGF)蛋白質家族的受體,位於細胞膜表面,屬於酪胺酸激酶受體的一種。PDGF的次單元A和次單元B在調控細胞增殖、分化、生長、發育上扮演相當重要的角色。如果調控不正常,可能會引發癌症等多種疾病。[2]
PDGF-R有兩種型態,分別為A和B,兩種型態來自於不同基因。[3]由於PDRF-R必須由兩者結合成為雙體之後才能作用,因此PDGFRA和PDGFRB可以互相組合或自我組合為均聚物(homodimerizes,即A配A、B配B)或雜二聚物(heterodimerizes,即A配B)[4]
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