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来自维基百科,自由的百科全书
腎小球基底膜(glomerular basement membrane、(GBM))是腎臟腎小球的基底膜層。腎小球毛細血管內皮細胞,腎小球基底膜及濾過裂隙介於足細胞之間執行腎小球的超濾作用(hyperfiltration),在鮑氏囊裡以濾過運作分離腎小球毛細血管的血液。[1] GBM是血管內皮細胞及足細胞基底層的結合。[2]
此條目可參照英語維基百科相應條目來擴充。 (2024年4月1日) |
GBM包含三個層次:[3]
Layer | Location | Composition | Function |
lamina rara externa | adjacent to podocyte processes | heparan sulfate | blocks by charge |
lamina densa | dark central zone | type 4 collagen and laminin | blocks by size (Molecular Weight > 5800kDa) |
lamina rara interna | adjacent to endothelial cells | heparan sulfate | blocks by charge |
腎小球膜由腎小球繫膜細胞,改性週細胞在體內分離毛細管彼此的其它部分。毗鄰他們足有直徑25納米是由他們引起的偽足形成過濾縫隙。過濾狹縫覆蓋有隔膜,其包括跨膜蛋白腎病蛋白。
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