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溶桿菌科（學名：Lysobacteraceae）為溶桿菌目的一科細菌。此科的模式屬為溶桿菌屬(Lysobacter)。
本科包括以下屬：
- Alkalisalibacterium Abidueva et al. 2023
- Alkalisalibacterium limincola Abidueva et al. 2023[1]
- 砂單胞菌屬 Arenimonas Kwon et al. 2007
- Aspromonas Jin et al. 2007
- Aspromonas composti Jin et al. 2007[2]
- Chujaibacter Kim et al. 2015
- Chujaibacter soli Kim et al. 2015
- Coralloluteibacterium Chen et al. 2018
- Coralloluteibacterium stylophorae Chen et al. 2018
- Coralloluteibacterium thermophilus You et al. 2018
- 藤黃單胞菌屬 Luteimonas Finkmann et al. 2000
- 溶桿菌屬 Lysobacter Christensen and Cook 1978
- Metallibacterium Ziegler et al. 2013
- Mizugakiibacter Kojima et al. 2014
- Pseudolysobacter Wei et al. 2020
- 假黃色單胞菌屬 Pseudoxanthomonas Finkmann et al. 2000
- Schineria Tóth et al. 2001
- Silanimonas Lee et al. 2005
- Silanimonas algicola Chun et al., 2017
- Silanimonas lenta Lee et al., 2005
- Silanimonas mangrovi Srinivas et al., 2013[3]
- 寡養單胞菌屬 Stenotrophomonas Palleroni and Bradbury 1993
- 熱單胞菌屬 Thermomonas Busse et al. 2002
- Vulcaniibacterium Yu et al. 2014
- Vulcaniibacterium tengchongense Yu et al., 2014[4]
- Vulcaniibacterium thermophilum (Wei et al., 2013) Yu et al., 2014
- 黃色單胞菌屬 Xanthomonas Dowson 1939
- 木桿菌屬 Xylella Wells et al. 1987
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