CDKN2B-AS亦被稱為ANRIL（INK4基因座中反義非編碼RNA，英語：antisense non-coding RNA in the INK4 locus）是一條由19個外顯子組成的長鏈非編碼RNA，在基因組中橫跨12.63萬個鹼基對，轉錄產物被剪接為長3834個鹼基的RNA。該長鏈位於p15CDKN2B-p16CDKN2A-p14ARF基因座中且與蛋白編碼基因呈反義方向轉錄。一些位於CDKN2B-AS的單核苷酸多態性位點（SNPs）改變其表達量，並與冠狀動脈性心臟病、糖尿病及多種癌症在內的許多疾病呈關聯性[1]。該條長鏈與多梳抑制複合物1中的克羅莫框7（CBX7）及多梳抑制複合物2中的SUZ12相結合，並通過與這兩種多梳蛋白相互作用引起其它基因轉錄沉默[2][3]。
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