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明憲宗成化年間，蔣琮為印綬監太監。明孝宗即位後，蔣琮任南京守備太監，將百姓開墾的沙洲指為蘆場，占奪民田，與民爭利。弘治二年，南京御史姜綰、給事中韓重彈劾蔣琮，最後蔣琮與南京御史姜綰相訐奏，致御史十人下獄。寬免蔣琮不問。當時劉吉討厭南京御史彈劾自己，故興大獄。尚書王恕、李敏，給事中趙竑，御史張賓說蔣琮、姜綰同罪異罰，失之公平，明孝宗不納。後因損毀皇陵等罪被劾，蔣琮最後免死，謫充孝陵淨軍。
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