SOX9

SOX9
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	4EUW
識別號
別名	SOX9；, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9
外部ID	OMIM：608160 MGI：98371 HomoloGene：294 GeneCards：SOX9
基因位置（人類）
染色體	17號染色體
終止	72,126,416 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	112,678,586 bp
RNA表現模式
	; ;
	查閱更多表現資料
基因本體
分子功能	• DNA結合轉錄因子活性; • DNA-binding transcription activator activity, RNA polymerase II-specific; • core promoter sequence-specific DNA binding; • 蛋白激酶活性; • protein kinase A catalytic subunit binding; • beta-catenin binding; • pre-mRNA intronic binding; • chromatin binding; • 血漿蛋白結合; • DNA結合; • sequence-specific DNA binding; • transcription cis-regulatory region binding; • bHLH transcription factor binding; • 核心啟動子近端區域序列特異性DNA結合; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II cis-regulatory region sequence-specific DNA binding;
細胞組分	• 細胞核; • 轉錄調節複合物; • 核質; • 大分子複合體;
生物學過程	• 骨骼系統的發生; • cellular response to retinoic acid; • bronchus cartilage development; • positive regulation of protein phosphorylation; • heart valve development; • limb bud formation; • positive regulation of protein catabolic process; • regulation of transcription by RNA polymerase II; • ureter morphogenesis; • negative regulation of immune system process; • chondrocyte development; • positive regulation of cell proliferation involved in heart morphogenesis; • oligodendrocyte differentiation; • chondrocyte hypertrophy; • prostate gland development; • lung smooth muscle development; • 乳腺發育; • negative regulation of ossification; • negative regulation of photoreceptor cell differentiation; • cellular response to mechanical stimulus; • intrahepatic bile duct development; • regulation of cell adhesion; • negative regulation of chondrocyte differentiation; • positive regulation of mesenchymal cell proliferation; • astrocyte fate commitment; • positive regulation of chondrocyte differentiation; • 精子發生; • prostate gland morphogenesis; • negative regulation of epithelial cell proliferation; • lung epithelial cell differentiation; • chondrocyte differentiation involved in endochondral bone morphogenesis; • negative regulation of canonical Wnt signaling pathway; • endocrine pancreas development; • negative regulation of cell population proliferation; • regulation of apoptotic process; • cellular response to transforming growth factor beta stimulus; • negative regulation of mesenchymal cell apoptotic process; • 染色體重建; • negative regulation of myoblast differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • cell fate commitment; • regulation of transcription, DNA-templated; • epidermal growth factor receptor signaling pathway; • 成骨作用; • regulation of cell proliferation involved in tissue homeostasis; • ureter smooth muscle cell differentiation; • ERK1 and ERK2 cascade; • notochord development; • positive regulation of epithelial cell migration; • Sertoli cell differentiation; • male sex determination; • negative regulation of gene expression; • transcription, DNA-templated; • metanephric nephron tubule formation; • positive regulation of transcription, DNA-templated; • 心臟發育; • regulation of branching involved in lung morphogenesis; • ureter urothelium development; • branching involved in ureteric bud morphogenesis; • 軟骨生成; • Harderian gland development; • positive regulation of kidney development; • central nervous system development; • heart valve formation; • positive regulation of cartilage development; • tissue homeostasis; • metanephric tubule development; • negative regulation of biomineral tissue development; • endochondral bone morphogenesis; • trachea cartilage development; • male germ-line sex determination; • 淚腺的發生; • Notch信號通路; • hair follicle development; • 細胞分化; • 輸尿管的發生; • regulation of cell cycle process; • male gonad development; • positive regulation of epithelial cell proliferation; • cell fate specification; • intestinal epithelial structure maintenance; • positive regulation of extracellular matrix assembly; • extracellular matrix organization; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • Sertoli cell development; • positive regulation of mesenchymal stem cell differentiation; • retina development in camera-type eye; • cellular response to interleukin-1; • 上皮-間充質轉換; • homeostasis of number of cells within a tissue; • negative regulation of transcription, DNA-templated; • cAMP-mediated signaling; • cartilage condensation; • positive regulation of male gonad development; • nucleosome assembly; • negative regulation of bone mineralization; • morphogenesis of a branching epithelium; • neural crest cell development; • Akt/PKB信號通路; • somatic stem cell population maintenance; • otic vesicle formation; • otic vesicle development; • endocardial cushion morphogenesis; • cellular response to epidermal growth factor stimulus; • positive regulation of epithelial cell differentiation; • renal vesicle induction; • positive regulation of gene expression; • regulation of epithelial cell proliferation involved in lung morphogenesis; • regulation of cell population proliferation; • heart valve morphogenesis; • 細胞骨架組織; • cochlea morphogenesis; • positive regulation of cell population proliferation; • epithelial cell proliferation involved in prostatic bud elongation; • retinal rod cell differentiation; • protein localization to nucleus; • regulation of cell differentiation; • positive regulation of phosphatidylinositol 3-kinase signaling; • cellular response to heparin; • negative regulation of epithelial cell differentiation; • epithelial tube branching involved in lung morphogenesis; • 訊息傳遞; • positive regulation of transcription by RNA polymerase II; • negative regulation of pri-miRNA transcription by RNA polymerase II; • chondrocyte differentiation; • neural crest cell fate specification; • cellular response to BMP stimulus; • cell-cell adhesion; • transcription initiation from RNA polymerase II promoter; • protein-containing complex assembly; • anterior head development; • morphogenesis of an epithelium; • aortic valve morphogenesis; • 基因調節;
	Sources:Amigo / QuickGO
直系同源
	6662
	20682
	ENSG00000125398
	ENSMUSG00000000567
	P48436
	Q04887
	NM_000346
	NM_011448
	NP_000337
	NP_035578
	維基資料
檢視/編輯人類	檢視/編輯小鼠

SOX9（英語：Transcription factor SOX-9）是一種轉錄因子，由人類基因Sox9編碼，是塞爾托利氏細胞等細胞的標誌物^[5]^[6]。

Quick Facts SOX9, 已知的結構 ...

Close

相互作用

SOX9可與類固醇生成因子1、MED12^[7]和MAF^[8]發生相互作用。

參考文獻

[1]
GRCh38: Ensembl release 89: ENSG00000125398 - Ensembl, May 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000000567 - Ensembl, May 2017
[3]
Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Tommerup N, Schempp W, Meinecke P, Pedersen S, Bolund L, Brandt C, et al. Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. Nature Genetics. June 1993, 4 (2): 170–4. PMID 8348155. S2CID 12263655. doi:10.1038/ng0693-170.
[6]
Entrez Gene: SOX9 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal). [2021-06-01]. （原始內容存檔於2010-03-07）.
[7]
Zhou R, Bonneaud N, Yuan CX, de Santa Barbara P, Boizet B, Schomber T, et al. SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Research. July 2002, 30 (14): 3245–52. PMC 135763 . PMID 12136106. doi:10.1093/nar/gkf443.
[8]
Huang W, Lu N, Eberspaecher H, De Crombrugghe B. A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene. The Journal of Biological Chemistry. December 2002, 277 (52): 50668–75. PMID 12381733. doi:10.1074/jbc.M206544200 .

外部連結

醫學主題詞表（MeSH）：SOX9+protein,+human
Template:UCSC genome browser
Template:UCSC gene details
PDB中UniProt可用的所有結構資訊之概述：P48436 (Human Transcription factor SOX-9) 在PDBe-KB（英語：PDBe-KB）。
PDB中UniProt可用的所有結構資訊之概述：Q04887 (Mouse Transcription factor SOX-9) 在PDBe-KB（英語：PDBe-KB）。

SOX9引用了美國國家醫學圖書館提供的資料，這些資料屬於公共領域。

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000125398 - Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000000567 - Ensembl, May 2017

[3] [3]
Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8348155-5] [5]
Tommerup N, Schempp W, Meinecke P, Pedersen S, Bolund L, Brandt C, et al. Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. Nature Genetics. June 1993, 4 (2): 170–4. PMID 8348155. S2CID 12263655. doi:10.1038/ng0693-170.

[entrez-6] [6]
Entrez Gene: SOX9 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal). [2021-06-01]. （原始內容存檔於2010-03-07）.

[pmid12136106-7] [7]
Zhou R, Bonneaud N, Yuan CX, de Santa Barbara P, Boizet B, Schomber T, et al. SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Research. July 2002, 30 (14): 3245–52. PMC 135763 . PMID 12136106. doi:10.1093/nar/gkf443.

[pmid12381733-8] [8]
Huang W, Lu N, Eberspaecher H, De Crombrugghe B. A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene. The Journal of Biological Chemistry. December 2002, 277 (52): 50668–75. PMID 12381733. doi:10.1074/jbc.M206544200 .

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]