SNAPC4

snRNA活化蛋白複合體第四亞基（英語：snRNA-activating protein complex subunit 4）是一個由人類基因 SNAPC4 編碼的蛋白質^[5][6]。

SNAPC4
識別號
別名	SNAPC4；, PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
外部ID	OMIM：602777 MGI：2443935 HomoloGene：2321 GeneCards：SNAPC4
基因位置（人類） 染色體 9號染色體[1] 基因座 9q34.3 起始 136,375,567 bp[1] 終止 136,400,176 bp[1]
基因位置（小鼠） 染色體 小鼠2號染色體[2] 基因座 2|2 A3 起始 26,252,777 bp[2] 終止 26,270,665 bp[2]
RNA表現模式
查閱更多表現資料
基因本體 分子功能 • DNA結合轉錄因子活性 • DNA結合 • sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific 細胞組分 • 細胞核 • 核質 • snRNA-activating protein complex 生物學過程 • regulation of transcription, DNA-templated • transcription by RNA polymerase II • transcription, DNA-templated • snRNA transcription by RNA polymerase III • transcription by RNA polymerase III • regulation of transcription by RNA polymerase II • snRNA transcription by RNA polymerase II • 細胞分化 • snRNA transcription Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	6621	227644
Ensembl	ENSG00000165684	ENSMUSG00000036281
UniProt	Q5SXM2	Q8BP86
mRNA​序列	NM_003086 ​NM_001394201 ​NM_001394202 ​NM_001394203	NM_001290419 ​NM_172339
蛋白序列	NP_003077	NP_001277348 ​NP_758842 ​NP_001393660 ​NP_001393661 ​NP_001393662 ​NP_001393663 ​NP_001393664 ​NP_001393665 ​NP_001393666 ​NP_001393667 ​NP_001393668
基因位置​（UCSC）	Chr 9: 136.38 – 136.4 Mb	Chr 2: 26.25 – 26.27 Mb
PubMed​查找	[3]	[4]
維基資料
檢視/編輯人類 檢視/編輯小鼠

相互作用

SNAPC4能與SNAPC1^[7]、POU2F1^[5][8]和SNAPC2^[5][7]相互作用。

參考文獻

1. GRCh38: Ensembl release 89: ENSG00000165684 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036281 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N. The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1. Mol Cell Biol. January 1998, 18 (1): 368–77. PMC 121507 . PMID 9418884. 引用錯誤：帶有name屬性「pmid9418884」的<ref>標籤用不同內容定義了多次
6. Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa.
7. Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200. 引文使用過時參數coauthors (幫助)
8. Hovde, Stacy; Brooks Aimee, Strong Katie, Geiger James H. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. (Denmark). March 2002, 58 (Pt 3): 511–2. ISSN 0907-4449. PMID 11856838. doi:10.1107/S0907444901021461. 引文使用過時參數coauthors (幫助)

延伸閱讀

• Henry RW, Sadowski CL, Kobayashi R, Hernandez N. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. Nature. 1995, 374 (6523): 653–6. PMID 7715707. doi:10.1038/374653a0.
• Ma B, Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. 2001, 276 (7): 5027–35. PMID 11056176. doi:10.1074/jbc.M009301200.
• Hovde S, Brooks A, Strong K, Geiger JH. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. 2002, 58 (Pt 3): 511–2. PMID 11856838. doi:10.1107/S0907444901021461.
• Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
• Hinkley CS; Hirsch HA; Gu L; et al. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. J. Biol. Chem. 2003, 278 (20): 18649–57. PMID 12621023. doi:10.1074/jbc.M204247200.
• Ota T; Suzuki Y; Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
• Humphray SJ; Oliver K; Hunt AR; et al. DNA sequence and analysis of human chromosome 9. Nature. 2004, 429 (6990): 369–74. PMC 2734081 . PMID 15164053. doi:10.1038/nature02465.
• Beausoleil SA; Jedrychowski M; Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
• Gu L, Esselman WJ, Henry RW. Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC. J. Biol. Chem. 2005, 280 (30): 27697–704. PMID 15955816. doi:10.1074/jbc.M503206200.
• Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW. The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III. J. Biol. Chem. 2007, 282 (38): 27887–96. PMID 17670747. doi:10.1074/jbc.M702269200.