PD-137889

PD-137889（N-甲基六氫芴胺）是一種化學化合物，中樞神經系統NMDA受體拮抗劑，效力比氯胺酮強約30倍^[1]，動物研究中可替代五氯苯酚。^[2][3][4]K_i[³H]TCP^[a] = 27 nM，氯胺酮K_i = 860 nM。 ^[5]

PD-137889
IUPAC名 (4aR)-N-Methyl-1,2,3,4,9,9a-hexahydro-4aH-fluoren-4a-amine
識別
CAS號	95372-93-3  Y 147128-60-7（rel-(4aR,9aS)）  Y
PubChem	10104280
ChemSpider	8279807
SMILES	c12c(cccc1)C3(NC)CCCCC3C2
InChI	1S/C14H19N/c1-15-14-9-5-4-7-12(14)10-11-6-2-3-8-13(11)14/h2-3,6,8,12,15H,4-5,7,9-10H2,1H3
InChIKey	KQLIVVYSTDBTMZ-UHFFFAOYSA-N
性質
化學式	C14H19N
摩爾質量	201.31 g·mol−1
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

參考

1. Hays, Sheryl J.; Novak, Perry M.; Ortwine, Daniel F.; Bigge, Christopher F.; Colbry, Norman L.; Johnson, Graham; Lescosky, Leonard J.; Malone, Thomas C.; Michael, Andre. Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor. J Med Chem. 1993, 36 (6): 654–70. PMID 8459395. doi:10.1021/jm00058a002.
2. Nicholson, Katherine L.; Balster, Robert L. Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats. Psychopharmacology. 2003, 170 (2): 215–224. PMID 2851738. S2CID 30803162. doi:10.1007/s00213-003-1527-6.
3. Bigge, Christopher F. Structural requirements for the development of potent n-methyl-d-aspartic acid (NMDA) receptor antagonists. Biochemical Pharmacology. 1993, 45 (8): 1547–1561. PMID 7683469. doi:10.1016/0006-2952(93)90294-7.
4. Bigge, Christopher F.; Malone, Thomas C. Overview: Agonists, Antagonists and Modulators of the N-methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) Subtypes of Glutamate Receptors. Current Opinion on Therapeutic Patents. 1993, 3 (7): 951–989. doi:10.1517/13543776.3.7.951.
5. Polycyclic amine derivatives useful as cerebrovascular agents （頁面存檔備份，存於網際網路檔案館） United States Patent; Coughenour, et al. Family ID: 22686445 Appl. #07/186,834

1. [³H]N-[1-(2-thienyl)cyclohex-yl]piperidine