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KLF4
位於9號人類染色體的基因 / 維基百科,自由的 encyclopedia
Kruppel樣因子4(英語:Kruppel-like factor 4,縮寫KLF4)或腸富集Krüppel樣因子(英語:gut-enriched Krüppel-like factor,縮寫GKLF)是鋅指轉錄因子KLF家族的一個成員,後者屬於一個較大的SP1(英語:Sp1 transcription factor)樣轉錄因子家族[5][6][7]。KLF4參與細胞增殖、細胞分化、細胞凋亡和體細胞重編程(英語:Reprogramming)的調節。有證據表明KLF4在包括大腸癌在內的一些癌症中是腫瘤抑制基因[8]。與KLF2(英語:KLF2)類似,它在C端有三個C2H2型鋅指[6]。它有兩個核定位序列指引它定位於細胞核內[9]。在胚胎幹細胞(ESCs)和間充質幹細胞(MSCs)中KLF4是顯示多能化的很好標記。
參考
- Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. doi:10.1002/jcp.1111.
- Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176
. PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.
- Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biology. 2003, 4 (2): 206. PMC 151296
. PMID 12620113. doi:10.1186/gb-2003-4-2-206.
- El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Molecular Cancer. August 2013, 12: 89. PMC 3750599
. PMID 23919723. doi:10.1186/1476-4598-12-89.
- Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085
. PMID 9218496. doi:10.1074/jbc.272.29.18504.
外部連結
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