開陽縣中國名。在今山東省臨沂市境。

春秋時期鄅國地,國君為妘姓,國都在啟陽邑。春秋末被魯國吞併。漢初,於此置啟陽縣漢景帝時,為避景帝名諱,改名為開陽縣。東漢為琅邪國治所,後來建安二十一年(216年)權臣曹操殺琅邪王劉熙,琅邪國除。北魏時,撤銷建制。

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