腎上腺素受體α1A(α1A adrenoreceptor),又稱為ADRA1A[6],是一種α1腎上腺素受體[7]。過去一度有α1C的分類,但在研究後認為α1C僅是α1A的一種亞型,因此取消該命名。為了避免混淆,之後新發現的亞型便從D開始繼續命名。
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腎上腺素受體α1共有3種亞型,包含α1A、α1B、α1D,全都屬於Gq/11家族的G蛋白。不同亞型的致活路徑有所差異,本類受體在體內主要內源性配體為腎上腺素,主要產生戰鬥或逃跑反應。
該蛋白的基因共有四種剪切方式,因此共有四種同型體。不同同型體可由其C端判別,但基本上功能相同[7]。
- 6-(5-fluoro-2-pyrimidin-5-yl-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole: EC50 = 1nM, Emax = 65%; good selectivity over α1B, α1D and α2A subtypes[8]
- further partial agonistic imidazole compounds[9][10]
- A-61603[11]
腎上腺素受體α1A可加強對於樹樹突觸的抑制[12]。
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