同源(异形)框(英语:Homeobox),或称“同源匣”是某些影响动物、真菌及植物发育的基因所拥有的一段DNA序列,拥有同源框的基因称作同源异形基因,统称同源异形基因家族。
Quick Facts Homeodomain, 鉴定 ...
Homeodomain |
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![Thumb](//upload.wikimedia.org/wikipedia/commons/thumb/c/cb/Homeodomain-dna-1ahd.png/220px-Homeodomain-dna-1ahd.png) The Antennapedia homeodomain protein from Drosophila melanogaster bound to a fragment of DNA. [1] The recognition helix and unstructured N-terminus are bound in the major and minor grooves respectively. |
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标志 | 同源框结构域(Homeodomain) |
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Pfam | PF00046(旧版) |
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Pfam宗系 | CL0123(旧版) |
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InterPro | IPR001356 |
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SMART | SM00389 |
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PROSITE | PDOC00027 |
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SCOP | 1ahd / SUPFAM |
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Pfam | 结构(旧版) / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | 结构概要 |
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PDB | 1ahd, 1akh, 1apl, 1au7, 1b72, 1b8i, 1bw5, 1cqt, 1du0, 1du6, 1e3o, 1enh, 1f43, 1fjl, 1ftt, 1ftz, 1gt0, 1hdd, 1hdp, 1hf0, 1hom, 1ic8, 1ig7, 1jgg, 1k61, 1kz2, 1le8, 1lfb, 1lfu, 1mh3, 1mh4, 1mnm, 1nk2, 1nk3, 1o4x, 1ocp, 1oct, 1p7i, 1p7j, 1pog, 1puf, 1qry, 1s7e, 1san, 1uhs, 1vnd, 1wi3, 1x2m, 1x2n, 1yrn, 1yz8, 1zq3, 1ztr, 2cqx, 2cra, 2cue, 2cuf, 2dmq, 2e1o, 2ecb, 2ecc, 2h8r, 2hdd, 2hi3, 2hoa, 2jwt, 2lfb, 2p81, 2r5y, 2r5z, 3hdd, 9ant |
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这段序列之长度约180个核苷酸,能转录出一段蛋白质结构域,称为同源框结构域。
PDB 1AHD; Billeter M, Qian YQ, Otting G, Müller M, Gehring W, Wüthrich K. Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex. Journal of Molecular Biology. Dec 1993, 234 (4): 1084–93. PMID 7903398. doi:10.1006/jmbi.1993.1661.