胸腺基质淋巴细胞生成素（英语：Thymic stromal lymphopoietin，缩写TSLP）是一种由人类基因 TSLP 编码的蛋白质，是与白细胞介素-2类似的细胞因子[6][7]，其受体α亚基与白细胞介素-7共用，β亚基由CRLF2基因编码[8]。 事实速览 胸腺基质淋巴细胞生成素, 已知的结构 ...胸腺基质淋巴细胞生成素已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表4NN5、4NN6、4NN7识别号别名TSLP；, thymic stromal lymphopoietin外部IDOMIM：607003 MGI：1855696 HomoloGene：81957 GeneCards：TSLP 相关疾病过敏性鼻炎[1]基因位置（人类）染色体5号染色体[2]基因座5q22.1起始111,070,062 bp[2]终止111,078,026 bp[2]基因位置（小鼠）染色体小鼠18号染色体[3]基因座18 B1|18 18.12 cM起始32,948,436 bp[3]终止32,952,850 bp[3]基因本体分子功能• 细胞因子活性• interleukin-7 receptor binding细胞组分• 细胞外空间• 细胞外区域生物学过程• regulation of signaling receptor activity• interleukin-7-mediated signaling pathway• positive regulation of cytokine-mediated signaling pathway• positive regulation of cell population proliferation• positive regulation of chemokine production• positive regulation of interleukin-10 production• positive regulation of interleukin-13 production• positive regulation of interleukin-5 production• positive regulation of interleukin-6 production• positive regulation of mast cell activation• positive regulation of tyrosine phosphorylation of STAT protein• negative regulation of apoptotic process• positive regulation of inflammatory response• defense response to Gram-negative bacterium• defense response to fungus• antimicrobial humoral immune response mediated by antimicrobial peptide• positive regulation of chemokine (C-C motif) ligand 1 production• positive regulation of granulocyte colony-stimulating factor production• positive regulation of receptor signaling pathway via STATSources:Amigo / QuickGO直系同源物种人类小鼠Entrez8548053603EnsemblENSG00000145777ENSMUSG00000024379UniProtQ969D9Q9JIE6mRNA序列NM_033035NM_138551NM_021367蛋白序列NP_149024NP_612561NP_067342基因位置（UCSC）Chr 5: 111.07 – 111.08 MbChr 18: 32.95 – 32.95 MbPubMed查找[4][5]维基数据查看/编辑人类查看/编辑小鼠关闭 参考文献 [1]與胸腺基质淋巴细胞生成素相關的疾病；在維基數據上查看/編輯參考. [2]GRCh38: Ensembl release 89: ENSG00000145777 - Ensembl, May 2017 [3]GRCm38: Ensembl release 89: ENSMUSG00000024379 - Ensembl, May 2017 [4]Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. [5]Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. [6]Ebina-Shibuya R, Leonard WJ. Role of thymic stromal lymphopoietin in allergy and beyond. Nature Reviews. Immunology. January 2023, 23 (1): 24–37. PMC 9157039 . PMID 35650271. doi:10.1038/s41577-022-00735-y. [7]Tsilingiri K, Fornasa G, Rescigno M. Thymic Stromal Lymphopoietin: To Cut a Long Story Short. Cellular and Molecular Gastroenterology and Hepatology. March 2017, 3 (2): 174–182. PMC 5331833 . PMID 28275684. doi:10.1016/j.jcmgh.2017.01.005. [8]Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. American Journal of Respiratory Cell and Molecular Biology. August 2016, 55 (2): 264–274. PMC 4979369 . PMID 26934097. doi:10.1165/rcmb.2015-0380OC. 外部链接 PDB中UniProt可用的所有结构信息之概述：Q969D9 (Thymic stromal lymphopoietin) 在PDBe-KB（英语：PDBe-KB）。Wikiwand - on Seamless Wikipedia browsing. On steroids.
