森沙夫定

森沙夫定（英语：Censavudine，开发代码：BMS-986001，也称为4'-乙炔基司他夫定，4'-ethynylstavudine）是一种含氮有机化合物，化学式为C₁₂H₁₂N₂O₄，由百时美施贵宝作为HIV抑制剂开发。^[1][2]

森沙夫定

临床资料
其他名称	4'-ethynylstavudine, festinavir
法律规范状态
法律规范	Investigational
识别信息
IUPAC命名法 1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methylpyrimidine-2,4-dione
CAS号	634907-30-5
PubChem CID	3008897
ChemSpider	2278330
UNII	6IE83O6NGA
KEGG	D10550
ChEMBL	ChEMBL124363
NIAID ChemDB	209894
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID50212893
ECHA InfoCard	100.225.812
化学信息
化学式	C12H12N2O4
摩尔质量	248.24 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@](O2)(CO)C#C
InChI InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1 Key:OSYWBJSVKUFFSU-SKDRFNHKSA-N

参考文献

1. Wu VH, Smith RA, Masoum S, Raugi DN, Ba S, Seydi M, et al. MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture. Antimicrobial Agents and Chemotherapy. August 2017, 61 (8). PMC 5527656 . PMID 28559249. doi:10.1128/AAC.00744-17.
2. Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, et al. Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial. The Lancet. HIV. January 2016, 3 (1): e13–22. PMID 26762988. doi:10.1016/S2352-3018(15)00231-3. hdl:1805/10552 .