普罗雌烯

普罗雌烯（INN：Promestriene，化学名：雌二醇-3-丙基-17β-甲基二醚，estradiol 3-propyl 17β-methyl diether，商品名有Colpotrofin、Colpotrophine、Delipoderm等）是一种有机化合物，化学式C
22H
32O
2，属于一种雌激素醚，以外用乳霜治疗妇女的萎缩性阴道炎。^{[1][2][3][4][5]}

普罗雌烯

临床资料
商品名（英语：Drug nomenclature）	Colpotrofin, Colpotrophine, Delipoderm
其他名称	Estradiol 3-propyl 17β-methyl diether; 17β-Methoxy-3-propoxyestra-1,3,5(10)-triene
给药途径	外用药物
药物类别	雌激素、雌激素醚
ATC码	G03CA09 (WHO)
识别信息
IUPAC命名法 (8R,9S,13S,14S)-17-methoxy-13-methyl-3-propoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene
CAS号	39219-28-8
PubChem CID	71717
ChemSpider	64767 Y
UNII	GXM4PER6WZ
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID2057730
ECHA InfoCard	100.049.401
化学信息
化学式	C22H32O2
摩尔质量	328.50 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CCCOc1ccc2c(c1)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4OC)C
InChI InChI=1S/C22H32O2/c1-4-13-24-16-6-8-17-15(14-16)5-7-19-18(17)11-12-22(2)20(19)9-10-21(22)23-3/h6,8,14,18-21H,4-5,7,9-13H2,1-3H3/t18-,19-,20+,21?,22+/m1/s1 N Key:IUWKNLFTJBHTSD-QIKJAYGVSA-N N

参考文献

1. Del Pup L, Di Francia R, Cavaliere C, Facchini G, Giorda G, De Paoli P, Berretta M. Promestriene, a specific topic estrogen. Review of 40 years of vaginal atrophy treatment: is it safe even in cancer patients?. Anti-Cancer Drugs. November 2013, 24 (10): 989–998. PMID 24080714. S2CID 3458356. doi:10.1097/CAD.0b013e328365288e.
2. Ganellin CR, Triggle DJ. Dictionary of Pharmacological Agents. CRC Press. 21 November 1996: 1671–. ISBN 978-0-412-46630-4.
3. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000: 1248, 1266, 1318, 1557. ISBN 978-3-88763-075-1.
4. William Andrew Publishing. Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. 22 October 2013: 270–271. ISBN 978-0-8155-1856-3.
5. Muller. European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. 19 June 1998: 289, 33 2. ISBN 978-3-7692-2114-5.