周期蛋白A1

Cyclin A1
周期素A1
Cyclin A1; 周期素A1
标识
代号	CCNA1
扩展标识	遗传学：604036 鼠基因：108042 同源基因：31203 ChEMBL: 3609 GeneCards: CCNA1 Gene
基因本体论描述
分子功能	· protein binding; · protein kinase binding;
细胞成分	· nucleoplasm; · cytosol; · microtubule cytoskeleton;
生物过程	· regulation of cyclin-dependent protein serine/threonine kinase activity; · G1/S transition of mitotic cell cycle; · regulation of transcription involved in G1/S phase of mitotic cell cycle; · G2/M transition of mitotic cell cycle; · mitotic cell cycle; · mitosis; · male meiosis I; · spermatogenesis; · cell division;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	8900
Ensembl	ENSG00000133101
UniProt	P78396
mRNA序列	NM_001111045
蛋白序列	NP_001104515
基因位置	Chr 13:; 37.01 – 37.02 Mb
PubMed查询	[1]
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周期蛋白A1（英语：Cyclin-A1，或译为周期素A1）是一个由人类基因 CCNA1 编码的蛋白质^[1]。

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该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白A1表达于睾丸、大脑以及一些严重的白血病细胞系中，现任为其主要功能是控制减数分裂。该周期蛋白与Cdk1和Cdk2两种激酶相结合，但这两种激酶活性完全不相同，前者激酶活性表现于G2期，而后者激酶活性表现于S期，因此在细胞周期中调控了不同的功能。现发现这种周期蛋白可结合到重要的细胞周期调节物上，后者如：Rb家族蛋白、转录因子E2F1以及CDK抑制蛋白中的Kip/Cip家族^[2]。

相互作用

周期蛋白A1能与E2F1^[3]、CDC20^[4]、视网膜母细胞瘤蛋白^[3]、周期蛋白依赖性激酶2（英语：Cyclin-dependent kinase 2）^[1]^[5]^[6]^[7]、GPS2（英语：GPS2 (gene)）^[8] MYBL2^[6]和GNB2L1^[8]发生相互作用。

参考文献

[1]
Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.
[2]
Entrez Gene: CCNA1 cyclin A1.
[3]
Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.
[4]
Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.
[5]
Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.
[6]
Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.
[7]
Brown, N R; Noble M E, Endicott J A, Johnson L N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.
[8]
Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.

延伸阅读

Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins.. Oncogene. 1995, 11 (8): 1581–8. PMID 7478582.
Xu M, Sheppard KA, Peng CY; et al. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.. Mol. Cell. Biol. 1994, 14 (12): 8420–31. PMC 359381 . PMID 7969176.
Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene. 1994, 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
O'Connor PM, Ferris DK, Pagano M; et al. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.. J. Biol. Chem. 1993, 268 (11): 8298–308. PMID 8463339.
Sweeney C, Murphy M, Kubelka M; et al. A distinct cyclin A is expressed in germ cells in the mouse.. Development. 1996, 122 (1): 53–64. PMID 8565853.
Wang H, Shao N, Ding QM; et al. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.. Oncogene. 1997, 15 (2): 143–57. PMID 9244350. doi:10.1038/sj.onc.1201252.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene. 1997, 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Liu D, Matzuk MM, Sung WK; et al. Cyclin A1 is required for meiosis in the male mouse.. Nat. Genet. 1998, 20 (4): 377–80. PMID 9843212. doi:10.1038/3855.
Yang R, Müller C, Huynh V; et al. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.. Mol. Cell. Biol. 1999, 19 (3): 2400–7. PMC 84032 . PMID 10022926.
Ravnik SE, Wolgemuth DJ. Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage.. Dev. Biol. 1999, 207 (2): 408–18. PMID 10068472. doi:10.1006/dbio.1998.9156.
Yang R, Nakamaki T, Lübbert M; et al. Cyclin A1 expression in leukemia and normal hematopoietic cells.. Blood. 1999, 93 (6): 2067–74. PMID 10068680.
Müller C, Yang R, Beck-von-Peccoz L; et al. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.. J. Biol. Chem. 1999, 274 (16): 11220–8. PMID 10196209. doi:10.1074/jbc.274.16.11220.
Ruffner H, Jiang W, Craig AG; et al. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.. Mol. Cell. Biol. 1999, 19 (7): 4843–54. PMC 84283 . PMID 10373534.
Brown NR, Noble ME, Endicott JA, Johnson LN. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases.. Nat. Cell Biol. 2001, 1 (7): 438–43. PMID 10559988. doi:10.1038/15674.
Liu D, Liao C, Wolgemuth DJ. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice.. Dev. Biol. 2000, 224 (2): 388–400. PMID 10926775. doi:10.1006/dbio.2000.9776.
Hartley JL, Temple GF, Brasch MA. DNA cloning using in vitro site-specific recombination.. Genome Res. 2001, 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Müller-Tidow C, Bornemann C, Diederichs S; et al. Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology.. FEBS Lett. 2001, 490 (1-2): 75–8. PMID 11172814. doi:10.1016/S0014-5793(01)02128-7.
Simpson JC, Wellenreuther R, Poustka A; et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.. EMBO Rep. 2001, 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Müller-Tidow C, Wang W, Idos GE; et al. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.. Blood. 2001, 97 (7): 2091–7. PMID 11264176. doi:10.1182/blood.V97.7.2091.

[pmid9041194-1] [1]
Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.

[entrez-2] [2]
Entrez Gene: CCNA1 cyclin A1.

[pmid10022926-3] [3]
Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.

[pmid10679238-4] [4]
Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.

[pmid8565853-5] [5]
Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.

[pmid11264176-6] [6]
Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.

[pmid10559988-7] [7]
Brown, N R; Noble M E, Endicott J A, Johnson L N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.

[pmid15159402-8] [8]
Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.

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